Results 111 to 120 of about 9,256,063 (344)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Research on the Loss of Three-level T-type Inverter in SVG

Kongzhi Yu Xinxi Jishu, 2015
It introduced topology structures of three-phase three-level T-type converter in SVG and its SVPWM modulation strategy,analyzed the conduction loss and switch loss of IGBT modules of the converters in different working conditions and gave the equations ...
CHEN Mingfeng, LEI Wanjun, FU Chongli, WANG Yue   +3 more
doaj  

A computer program to evaluate the effectiveness of PCM frame synchronization strategies [PDF]

Computer program simulating pulse code modulation /PCM/ conversion equipment using Monte Carlo technique in measuring strategy effectiveness of satellite equipment control ...
Narrow, B. G., Pasternack, M.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The WRHE-PWM Strategy With Minimized THD to Suppress High-Frequency Resonance Instability in Railway Traction Power Supply System

IEEE Access, 2019
Aiming at the high-frequency resonance instability phenomenon in high-speed railways and traction network (simplified as “train-network”) system, a new modulation strategy is proposed.
Xinyu Zhang, Jie Chen, Gang Zhang, Ruichang Qiu, Zhigang Liu   +4 more
doaj   +1 more source

Module Implementation and Modulation Strategy for Sensorless Balancing in Modular Multilevel Converters

IEEE transactions on power electronics, 2019
Modules with series and parallel connectivity add new features and operation modes to modular multilevel converters (MMCs). Compared to full- and half-bridges, the series/parallel modules allow sensorless module balancing and reduce conduction loss with ...
Zhongxi Li, R. Lizana F., Sha Sha, Zhujun Yu, A. Peterchev, S. Goetz   +5 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Game-Theoretic Approach to Energy-Efficient Modulation in CDMA Networks with Delay Constraints

, 2007
A game-theoretic framework is used to study the effect of constellation size on the energy efficiency of wireless networks for M-QAM modulation. A non-cooperative game is proposed in which each user seeks to choose its transmit power (and possibly ...
Goldsmith, Andrea J., Meshkati, Farhad, Poor, H. Vincent, Schwartz, Stuart C.   +3 more
core   +2 more sources