Results 51 to 60 of about 385,127 (266)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The role of dietary strategies in the modulation of hallmarks of aging

Ageing Research Reviews, 2023
The hallmarks of aging constitute an interconnected network of basic mechanisms that modulate aging and can be modulated by lifestyle factors, including dietary strategies. This narrative review aimed to summarize the evidence on promoting dietary restriction or adherence to specific dietary patterns on hallmarks of aging.
Grande de França, Natasha, Rolland, Yves, Gillette-Guyonnet, Sophie, Barreto de Souto, Philipe   +3 more
openaire   +2 more sources

A Zero-Sequence Steerable CBPWM Strategy for Eliminating Zero-Sequence Current of Dual-Inverter Fed Open-End Winding Transformer Based PV Grid-Tied System With Common DC Bus

IEEE Access, 2020
Aiming at the issue of zero-sequence current (ZSC) in the dual-inverter fed open-end winding transformer (OEWT-DI) based photovoltaic (PV) grid-tied system with common DC bus, a carrier-based pulse width modulation (CBPWM) strategy with steerable zero ...
Baoji Wang, Xing Zhang, Renxian Cao
doaj   +1 more source

High‐frequency pulse width modulation noise reduction for permanent magnet synchronous motors using hybrid asymmetrical regular sampled modified space‐vector pulse width modulation

IET Power Electronics, 2021
This paper proposes a strategy called hybrid asymmetrical regular sampled modified space‐vector pulse width modulation technique in two‐level voltage source inverters.
Wentao Zhang, Yongxiang Xu, Guodong Yu, Jibin Zou   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Novel High Power Factor and Soft Switching SAB-SWISS Rectifier With High-Low-High-Low Modulation and Hybrid Frequency Control

IEEE Access
A novel SWISS rectifier based on single active bridge converter (SAB-SR) is proposed. The high-low-high-low (HLHL) voltage waveform modulation to realize soft-switching for the power switches and the hybrid frequency control scheme to achieve high power ...
Bo Zeng, Ziwen Yang, Shi Yan, Lingjuan Tan, Shaojun Xie   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Material Strategies for Modulating Epithelial to Mesenchymal Transitions

ACS Biomaterials Science & Engineering, 2017
Epithelial to mesenchymal transitions (EMT) involve the phenotypic change of epithelial cells into fibroblast-like cells. This process is accompanied by the loss of cell-cell contacts, increased extracellular matrix (ECM) production, stress fiber alignment, and an increase in cell mobility. While essential for development and wound repair, EMT has also
Emily P. Mihalko, Ashley C. Brown
openaire   +3 more sources