Results 141 to 150 of about 233,212 (303)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Visual modulation transfer function as a predictor of acuity
, 1981 The use of Fourier and modulation transfer techniques implies the ability to characterize an optical system and predict the output resulting from various inputs. In this study, the optical system is defined as a projection system, rear projection screen,
Sebring, Thomas A.
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 2010 Liquid crystals have been recognized as practical adaptive optical components for imaging and nonimaging applications. We have studied a liquid crystal lens without power modulation, as distinct from a focus modulating lens, and have simulated the ...
Chung-Ming Ou +2 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Effect of Spot Size on the Fractal Optical Modulation
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 The present paper analyzes the signal emitting from the Reticle during changing the spot size of laser falling on the disk and shows the optimum frequency and the amount of energy window in different patterns of modulator (Reticle).
A. A S Mohammad +2 more
doaj
, 2007 We experimentally investigate the parameters affecting parametric transfer in a synchronously pumped optical parametric oscillator for indirect shaping of mid-infrared ultrashort pulses and make comparisons with previously reported numerical modeling ...
Hung, H.S. +9 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
IEEE AccessThe Dual Active Bridge (DAB) converter offers several advantages, including high power conversion efficiency and improved safety by providing galvanic isolation between the input and output through the use of a high-frequency transformer and H-bridge ...
Tae-Hyeon Lim, Jin-Su Jang, Gi-Young Lee
doaj +1 more source