Results 21 to 30 of about 776,397 (353)
Beilstein Journal of Organic Chemistry, 2020 A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU.
Yong Li +8 more
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A verified equivalent-circuit model for slotwaveguide modulators [PDF]
, 2019 We formulate and experimentally validate an equivalent-circuit model based on distributed elements to describe the electric and electro-optic (EO) properties of travellingwave silicon-organic hybrid (SOH) slot-waveguide modulators.
Freude, Wolfgang +9 more
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Modulating GABA modulators [PDF]
British Journal of Pharmacology, 2006 Benzodiazepines produce a broad spectrum of behavioral effects, which may be clinically desirable or undesirable, by positively or negatively modulating the effects of GABA at GABAA receptors. Over the past 20 years, much effort has been devoted towards identifying new compounds with limited undesirable effects.
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Nanophotonics, 2021 The phase modulator is a key component in optical communications for its phase modulation functions. In this paper, we numerically demonstrate a variety of ultra-compact high-efficiency graphene phase modulators (GPMs) based on metal–nanoribbon ...
Ye Longfang +5 more
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Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]
, 2016 NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E +2 more
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Letters in Mathematical Physics, 2009 Developing the ideas of Bressler and Soibelman and of Karabegov, we introduce a notion of an oscillatory module on a symplectic manifold which is a sheaf of modules over the sheaf of deformation quantization algebras with an additional structure. We compare the category of oscillatory modules on a torus to the Fukaya category as computed by Polishchuk ...
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Old drugs are new again (drugs) [PDF]
Serbian Journal of Anesthesia and Intensive Therapy, 2017 The societal cost of development of new medications is high. The faster and more economical approach is to use already proven pharmacological characteristics of drugs in use for development of new drug formulations.
Jovičić Jelena +5 more
doaj +1 more source
Supporting the identification of novel fragment-based positive allosteric modulators using a supervised molecular dynamics approach: A retrospective analysis considering the human A2A adenosine receptor as a key example [PDF]
, 2017 Structure-driven fragment-based (SDFB) approaches have provided efficient methods for the identification of novel drug candidates. This strategy has been largely applied in discovering several pharmacological ligand classes, including enzyme inhibitors ...
Deganutti, Giuseppe, Moro, Stefano
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Frontiers in Neuroscience, 2020 γ-Aminobutyric-acid type A (GABAA) receptors expressing the γ1 or γ3 subunit are only found within a few regions of the brain, some of which are involved in sleep.
Grant Richter +3 more
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Recent progress in terahertz metamaterial modulators
Nanophotonics, 2022 The terahertz (0.1–10 THz) range represents a fast-evolving research and industrial field. The great interest for this portion of the electromagnetic spectrum, which lies between the photonics and the electronics ranges, stems from the unique and ...
Degl’Innocenti Riccardo +2 more
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