Results 71 to 80 of about 271,149 (318)

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Frontiers in Pharmacology, 2021
Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins.
Ramu Manjula, Kumari Anuja, Francisco J. Alcain, Francisco J. Alcain   +3 more
doaj   +1 more source

Contribución al modelado y diseño de moduladores sigma-delta en tiempo continuo de baja relación de sobremuestreo y bajo consumo de potencia [PDF]

, 2005
Los moduladores Sigma-Delta de tiempo continuo constituyen una técnica de conversión de señal analógica a señal digital que resulta ser una alternativa interesante para aplicaciones de alta velocidad.
Patón Álvarez, Susana
core  

Comparative study of the MASH digital delta-sigma modulators [PDF]

, 2009
The paper focuses on the Multi-stAge noise SHaping (MASH) digital delta-sigma modulator (DDSM) that employs multi-moduli (MM-MASH). Different architectures of the MASH DDSM are compared.
Xu, Tao, Condon, Marissa, Marissa Condon, Tao Xu   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Role of mitophagy in spinal cord ischemia-reperfusion injury

Neural Regeneration Research
Spinal cord ischemia-reperfusion injury, a severe form of spinal cord damage, can lead to sensory and motor dysfunction. This injury often occurs after traumatic events, spinal cord surgeries, or thoracoabdominal aortic surgeries.
Yanni Duan, Fengguang Yang, Yibao Zhang, Mingtao Zhang, Yujun Shi, Yun Lang, Hongli Sun, Xin Wang, Hongyun Jin, Xuewen Kang   +9 more
doaj   +1 more source

S945L-CFTR molecular dynamics, functional characterization and tezacaftor/ivacaftor efficacy in vivo and in vitro in matched pediatric patient-derived cell models

Frontiers in Pediatrics, 2022
Cystic Fibrosis (CF) results from over 400 different disease-causing mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. These CFTR mutations lead to numerous defects in CFTR protein function.
Katelin M. Allan, Katelin M. Allan, Miro A. Astore, Laura K. Fawcett, Laura K. Fawcett, Laura K. Fawcett, Sharon L. Wong, Sharon L. Wong, Po-Chia Chen, Renate Griffith, Adam Jaffe, Adam Jaffe, Adam Jaffe, Serdar Kuyucak, Shafagh A. Waters, Shafagh A. Waters, Shafagh A. Waters, Shafagh A. Waters   +17 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

On coefficient modules of arbitrary modules

Proceedings of the Edinburgh Mathematical Society
Abstract Let $(R, \mathfrak{m})$ be a d -dimensional Noetherian local ring that is formally equidimensional, and let
Pedro Lima, Marcela Ferrari, Victor Jorge Pérez   +2 more
openaire   +2 more sources

Bit-stream-based space vector modulators

, 2012
Bit-stream-based control, which uses one bit wide signals to control power electronics applications, is a new approach for controller design in power electronic systems. This study presents a novel family of three-phase space vector modulators, which are
Vilathgamuwa, D. Mahinda, Madawala, Udaya K., Patel, N., Bradshaw, J.   +3 more
core   +1 more source