Results 81 to 90 of about 271,149 (318)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Accurate stability prediction of single-bit higher-order delta-sigma (Δ-Σ) modulators for speech codecs

, 2011
Present approaches for predicting the stability of Delta-Sigma (Δ-Σ) modulators are mostly confined to DC inputs. This poses limitations as practical applications of Δ-Σ modulators involve a wide range of signals other than DC such as speech, audio and ...
Lota, J., Al-Janabi, M.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications

Drugs and Drug Candidates
Current treatment options for Alzheimer’s disease target neurotransmitters following the disease onset, and they offer limited efficacy without slowing down the disease progression.
Nagaraju Bandaru, Sarad Pawar Naik Bukke, Veera Mani Deepika Pedapati, Gurugubelli Sowjanaya, Vangmai Swaroopa Suggu, Swathi Nalla, Prashik Bhimrao Dudhe, Joseph Obiezu Chukwujekwu Ezeonwumelu, Abdullateef Isiaka Alagbonsi, Hope Onohuean   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Design of Ultracompact High‐Speed‐Integrated Lithium–Niobate Periodic Dielectric Waveguide Modulator

Advanced Photonics Research, 2022
Modern communications and microwave photonics require compact electro‐optic modulators with ultrahigh bandwidth and low power consumption. These requirements can be satisfied by integrated lithium–niobate electro‐optic modulators with high bandwidth and ...
Yifan Qi, Zheng Zhang, Wenhe Jia, Sai Chen, Yuanmu Yang, Yang Li   +5 more
doaj   +1 more source

Tunable centre frequency resonator based bandpass Σ-Δ modulators

, 1998
This paper presents a methodology for the design of oversampled narrow-band single-loop and multi-stage resonator-based bandpass Σ-Δ modulators that can accommodate different passband centre to sampling frequency ratios.
Morling, R.C.S., Kale, I., Al-Janabi, M.
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis

Frontiers in Immunology
BackgroundCFTR modulator therapies have positive clinical outcomes, yet chronic inflammation and bacterial infections persist in people with CF (pwCF).
Hazel Ozuna, Hazel Ozuna, Dinesh Bojja, Santiago Partida-Sanchez, Luanne Hall-Stoodley, Amal Amer, Rodney D. Britt, Rodney D. Britt, Shahid Sheikh, David A. Frank, Weiyuan Wang, Bum-Yong Kang, Bum-Yong Kang, Irina Miralda, Irina Miralda, Samantha L. Durfey, Samantha L. Durfey, Benjamin T. Kopp, Benjamin T. Kopp   +18 more
doaj   +1 more source