Results 121 to 130 of about 361,214 (268)
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning
Advanced Science, EarlyView.Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao +14 more
wiley +1 more source
Advanced Science, EarlyView.Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang +12 more
wiley +1 more source
From Grave to Cradle: Kombucha Waste for Sustainable Electronics
Advanced Science, EarlyView.This study introduces a sustainable method to purify kombucha bacterial cellulose (KBC) with sodium bicarbonate and hydrogen peroxide, avoiding harsh chemicals. KBC films are patterned with gold and function as pressure sensors for flatfoot gait detection. At the end‐of‐life, the KBC‐based device biodegrades in soil, leaving environmentally benign gold
Xin Ying Chan +6 more
wiley +1 more source
Advanced Science, EarlyView.To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo +3 more
wiley +1 more source
Advanced Science, EarlyView.Dimethylsulfoniopropionate (DMSP) is a major marine organosulfur compound central to climate‐relevant dimethyl sulfide (DMS) production. In Halomonas sp. D47, DMSP catabolism is revealed to be coordinated by two transcriptional regulators, AcuR and AcuZ, which control gene expression by sensing DMSP and its metabolites.
Li‐Yuan Zheng +16 more
wiley +1 more source
EPS-MoE: Expert Pipeline Scheduler for Cost-Efficient MoE Inference
The Mixture-of-Experts (MoE) model has emerged as a prominent architecture in the field of Large Language Models (LLMs), providing a better balance between model performance and computational efficiency. However the General Matrix Multiply (GEMM) operations and large parameters introduce challenges related to computational efficiency and communication ...
Qian, Yulei +6 more
openaire +2 more sources
Super‐Robust Telecommunications Enabled by Topological Half‐Supermodes
Advanced Science, EarlyView.Through topological half‐supermode engineering, we realize a valley‐ridge gap waveguide that is directly compatible with conventional waveguides and features topological protection. This design halves the lateral size via a PEC boundary, enabling direct TE₁₀‐mode matching and robust bend‐immune transmission.
Rui Zhou +8 more
wiley +1 more source
MoE-PHDS: One MoE checkpoint for flexible runtime sparsity
Sparse Mixtures of Experts (MoEs) are typically trained to operate at a fixed sparsity level, e.g. $k$ in a top-$k$ gating function. This global sparsity level determines an operating point on the accuracy/latency curve; currently, meeting multiple efficiency targets means training and maintaining multiple models.
Hannah, Lauren. A +6 more
openaire +2 more sources