Results 21 to 30 of about 137,288 (297)
BioResources, 2016 The effect of thermal treatment temperatures on the dynamic and static modulus of elasticity (MOE) of Norway spruce wood (Picea abies (L.) H. Karst.) was evaluated.
Tomáš Holeček +4 more
doaj +1 more source
Market-value of Renewables in the Young Mexican Power Market
Revista Mexicana de Economía y Finanzas Nueva Época REMEF, 2022 Valor de las energías renovables en el joven mercado mexicano Esta investigación pretende encontrar el efecto que las renovables tienen para reducir el precio de la electricidad en México (“merit-order effect” o “MOE”). Usando datos del 01/enero/2017 al
David Talavera-Zabre
doaj +1 more source
Towards MoE Deployment: Mitigating Inefficiencies in Mixture-of-Expert (MoE) Inference
CoRR, 2023 Mixture-of-Experts (MoE) models have gained popularity in achieving state-of-the-art performance in a wide range of tasks in computer vision and natural language processing. They effectively expand the model capacity while incurring a minimal increase in computation cost during training.
Haiyang Huang 0003 +8 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
LLaDA-MoE: A Sparse MoE Diffusion Language Model
CoRRWe introduce LLaDA-MoE, a large language diffusion model with the Mixture-of-Experts (MoE) architecture, trained from scratch on approximately 20T tokens. LLaDA-MoE achieves competitive performance with significantly reduced computational overhead by maintaining a 7B-parameter capacity while activating only 1.4B parameters during inference.
Fengqi Zhu +25 more
openaire +3 more sources
Frontiers in Pharmacology, 2022 Background/Aim: Depression-related aggression is linked to serotonin (5-HT) and dendritic spine alterations. Although Mallotus oppositifolius extract (MOE) has potential for reducing this effect, its specific role remains uncertain.
Kennedy K.E. Kukuia +9 more
doaj +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son +3 more
wiley +1 more source