Results 81 to 90 of about 365,643 (284)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Performance of Laminated Veneer Lumber Panels from Fast-Growing Species with Different Layering Arrangements

BioResources
This study investigated the effect of various layer arrangements and their impact on the properties of laminated veneer lumber (LVL). Seven different layer arrangements (CCCCCCC, DDDDDDD, PPPPPPP, CDDDDDC, CPPPPPC, CDDCDDC, CPPCPPC, CDCDCDC, CPCPCPC ...
Mohammad Arabi, Moharam Hazrati, Akbar Rostampour-Haftkhani   +2 more
doaj   +2 more sources

Maxwell Herzlich, percussion, April 23, 2016 [PDF]

, 2016
This is the concert program of the Maxwell Herzlich, percussion performance on Saturday, April 23, 2016 at 2:00 p.m., at the College of Fine Arts Room 171, 855 Commonwealth Avenue.
School of Music, Boston University
core  

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Predicting the young’s modulus of defect free radiata pine shooks in finger-jointing using resonance frequency

Maderas: Ciencia y Tecnología, 2014
In this paper, dynamic MOE and static MOE of short-length radiata pine specimens produced for finger jointing were measured using non-destructive technique and correlated to each other.
How S.S, C.J Williamson, D. Carradine, Y.E Tan, J. Cambridge, S. Pang   +5 more
doaj  

Predicting Ship Main Engine Fuel Oil Consumption Using a Mixture of Experts Approach

IEEE Access
Predicting ship fuel oil consumption is crucial for optimizing fuel efficiency, reducing operational costs, and minimizing environmental impact. Prior work uses either shallow machine learning (ML) algorithms (e.g., AdaBoost, Bagging, ExtraTrees, Random ...
Loukas Ilias, Afroditi Blika, Ariadni Michalitsi-Psarrou, Spiros Mouzakitis, Dimitris Askounis   +4 more
doaj   +1 more source

Kajian Sosiolinguistik Kata Moe yang Digunakan dalam Komunitas Otaku Jepang [PDF]

, 2016
This research aimed at finding out variation of word form, meaning, and function of moe word which is used by Otaku Japanese Community. This research used some theories from J.D Parera (2004), Sudjianto and Ahmad Dahidi (2007), and from Abdul Chaer and ...
Aibonotika, A. (Arza), Susanti, E. (Erni), Widiati, S. W. (Sri)   +2 more
core  

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Comparative analysis of three different methods used to determine the elastic modulus for a choice of Tropical Guianese wood species [PDF]

, 2017
This study compares variability in the longitudinal Modulus of Elasticity (MOE) values, measured by three different methods, for eight tropical wood species covering a wide range of densities, a property that has been little described in the literature ...
Beauchêne, Jacques, Mehinto, Théophile, Pierrejean, Isabelle   +2 more
core  

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source