Results 41 to 50 of about 363,089 (289)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Moisture Origin and Transport for Extreme Precipitation over Indonesia’s New Capital City, Nusantara in August 2021

open access: yesAtmosphere, 2022
Nusantara, Indonesia’s new capital city, experienced a rare extreme rainfall event on 27–28 August 2021. This heavy rainfall occurred in August, the driest month of the year based on the monthly climatology data, and caused severe flooding and landslides.
Anis Purwaningsih   +8 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Simulations of Moisture Gradients in Wood Subjected to Changes in Relative Humidity and Temperature Due to Climate Change

open access: yesGeosciences, 2018
Climate change is a growing threat to cultural heritage buildings and objects. Objects housed in historic buildings are at risk because the indoor environments in these buildings are difficult to control and often influenced by the outdoor climate ...
Charlotta Bylund Melin   +4 more
doaj   +1 more source

Infiltration into inclined fibrous sheets [PDF]

open access: yes, 2004
The flow from line and point sources through an inclined fibrous sheet is studied experimentally and theoretically for wicking from a saturated region and flow from a constant-flux source.
Cottenden, A, Eames, I, Landeryou, M
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Long-term variability, extremes and changes in temperature and hydrometeorology in the Amazon region: A review [PDF]

open access: yesActa Amazonica
This review discusses observed hydroclimatic trends and future climate projections for the Amazon. Warming over this region is a fact, but the magnitude of the warming trend varies depending on the datasets and length of the analyzed period.
Jose Antonio MARENGO   +6 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

The increasing influence of atmospheric moisture transport on hydrometeorological extremes in the Euromediterranean region with global warming

open access: yesCommunications Earth & Environment
The Euromediterranean area is a key region in which the link between atmospheric moisture transport and hydrometeorological extremes concerns. Atmospheric rivers, the main moisture transport mechanism affecting the region, play a notable role in extreme ...
Luis Gimeno-Sotelo   +4 more
doaj   +1 more source

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