Results 61 to 70 of about 3,487,627 (302)

Characterization of Non-Specific Uptake and Retention Mechanisms of [¹⁷⁷Lu]Lu-PSMA-617 in the Salivary Glands

Pharmaceuticals, 2023
The radionuclide therapy [177Lu]Lu-PSMA-617 was recently FDA-approved for treatment of metastatic castration-resistant prostate cancer. Salivary gland toxicity is currently considered as the main dose-limiting side effect.
Nathalie Heynickx, Charlotte Segers, Amelie Coolkens, Sarah Baatout, Koen Vermeulen   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine

Journal of Extracellular Vesicles, 2018
Extracellular vesicles (EVs) have a great potential in clinical applications. However, their isolation from different bodily fluids and their characterisation are currently not optimal or standardised.
Eline Oeyen, Kurt Van Mol, Geert Baggerman, Hanny Willems, Kurt Boonen, Christian Rolfo, Patrick Pauwels, An Jacobs, Karin Schildermans, William C Cho, Inge Mertens   +10 more
doaj   +1 more source

Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development

Biology Open, 2015
Ionizing radiation is a potent activator of the tumor suppressor gene p53, which itself regulates the transcription of genes involved in canonical pathways such as the cell cycle, DNA repair and apoptosis as well as other biological processes like ...
Roel Quintens, Tine Verreet, Ann Janssen, Mieke Neefs, Liselotte Leysen, Arlette Michaux, Mieke Verslegers, Nada Samari, Giuseppe Pani, Joris Verheyde, Sarah Baatout, Mohammed A. Benotmane   +11 more
doaj   +1 more source

The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on the In Vitro Wound Healing Process

Cells, 2023
Human spaceflight is associated with several health-related issues as a result of long-term exposure to microgravity, ionizing radiation, and higher levels of psychological stress.
Wilhelmina E. Radstake, Kiran Gautam, Silvana Miranda, Randy Vermeesen, Kevin Tabury, Emil Rehnberg, Jasmine Buset, Ann Janssen, Liselotte Leysen, Mieke Neefs, Mieke Verslegers, Jürgen Claesen, Marc-Jan van Goethem, Uli Weber, Claudia Fournier, Alessio Parisi, Sytze Brandenburg, Marco Durante, Bjorn Baselet, Sarah Baatout   +19 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

PEMBERIAN MOL KEONG MAS DAN PUPUK KANDANG AYAM TERHADAP PERTUMBUHAN DAN HASIL KACANG NAGARA DI LAHAN GAMBUT

Ziraa'ah: Majalah Ilmiah Pertanian
This research aims to examine the effect of the interaction of golden snail MOL with chicken manure on the growth and yield of nagara bean plants and to examine the best combination of golden snail MOL and chicken manure on the growth and yield of nagara
Toria Magistra, Raihani Wahdah, Noor Aidawati   +2 more
doaj   +1 more source

Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons

Cells, 2019
The exposure of mouse embryos in utero and primary cortical neurons to ionizing radiation results in the P53-dependent activation of a subset of genes that is highly induced during brain development and neuronal maturation, a feature that these genes ...
André Claude Mbouombouo Mfossa, Helene Thekkekara Puthenparampil, Auchi Inalegwu, Amelie Coolkens, Sarah Baatout, Mohammed A. Benotmane, Danny Huylebroeck, Roel Quintens   +7 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Designer molecular probes for phosphonium ionic liquids [PDF]

, 2010
Investigations into the extent of structuring present in phosphonium based ionic liquids (ILs) have been carried out using photochromic molecular probes.
Armand, Baker, Breitbach, Byrne, Byrne, Byrne, Byrne, Coleman, Coleman, Crowhurst, Daibin, Dermot Diamond, di Nunzio, Fletcher, Fraser, Gorner, Hanioka, Ipe, Iwata, Iwata, Kalhor, Karmakar, Karmakar, Lopes, Lopes, Mandal, McCoy, Meng, Minkin, Pison, Radu, Ramnial, Reichardt, Robert Byrne, Rosario, Seiichi, Simon Coleman, Simon Gallagher, Singh, Stracke, Sueishi, Tsubaki, Uznanski, Uznanski, Wohl, Wu, Yuanyuan   +46 more
core   +1 more source