Results 111 to 120 of about 8,274,500 (305)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Modelos preclínicos en oncología molecular: hacia una medicina personalizada [PDF]
, 2016 La profesora invitada ha desarrollado un taller de resolución de un caso práctico con y para los alumnos de la asignatura "Biología Molecular del Cáncer" (optativa de 4º curso del Grado en Bioquímica)El objetivo de esta actividad práctica es ilustrar ...
Jiménez Cuenca, Benilde
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Trends in the Molecular Pathogenesis and Clinical Therapeutics of Common Neurodegenerative Disorders
, 2009 The term neurodegenerative disorders, encompasses a variety of underlying conditions, sporadic and/or familial and are characterized by the persistent loss of neuronal subtypes.
Girish Modi +6 more
core +1 more source
Cancer Management and Research, 2021 Dina Ioffe,* Pooja Phull,* Efrat Dotan Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA*These authors contributed equally to this workCorrespondence: Efrat DotanDepartment of Medical Oncology, Fox Chase Cancer ...
Ioffe D, Phull P, Dotan E
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Grading breast cancer tissues using molecular portraits.
, 2013 Tumor progression and prognosis of breast cancer patients is difficult to assess using current clinical and laboratory parameters, where a pathological grading is indicative of tumor aggressiveness.
Malmström, Per, +19 more
core +1 more source
Molecular Attraction, VI. [PDF]
The Journal of Physical Chemistry, 1907 n ...
openaire +6 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source