Results 101 to 110 of about 4,938,802 (269)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Clinical aspects of human Bocavirus 1 in a sample of Egyptian infants with acute lower respiratory tract infection: A pilot study

Journal of the Arab Society for Medical Research
Background/aim The recent advance in molecular technology permitted a comprehensive range of novel viral etiological causes to be detected in respiratory tract specimens.
Tayseer M. El-Zayat, Hala G. El-Nady, Soheir I. Mohamed, Amira S. El Refay, Ahmed N. El Tawel, Mona Gaber, Mohamed A. Ali   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Molecular Beamforming for Actuation in Molecular Communication Networks

IEEE Transactions on NanoBioscience
The actuation accuracy of sensing tasks performed by molecular communication (MC) schemes is a very important metric. Reducing the effect of sensors fallibility can be achieved by improvements and advancements in the sensor and communication networks design.
Joana Angjo, Ali E. Pusane, H. Birkan Yilmaz, Ertugrul Basar, Tuna Tugcu   +4 more
openaire   +3 more sources

Assessing Diagnostic Performance of Molecular Culture for Neonatal Sepsis: Protocol of the CHAMPIONS Study

Diagnostics
Managing neonatal sepsis is challenging due to nonspecific clinical signs, hematological markers with poor accuracy, and a lengthy turnaround time for the identification of microorganisms.
Jip Groen, Martijn van der Kuip, Dries Budding, Martine P. Bos, Marc A. Benninga, Hendrik J. Niemarkt, Tim G. J. de Meij   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Epidemiology and economics of foot-and-mouth disease: current understanding and knowledge gaps

Veterinary Research
Foot-and-mouth disease virus (FMDV) is one of the few veterinary pathogens that defines policy and global trade in animal products. Its prominence necessitates approaches to control that integrate the multiple factors contributing to the disease’s ...
John M. Humphreys, Carolina Stenfeldt, Donald P. King, Theodore Knight-Jones, Andres M. Perez, Kimberly VanderWaal, Michael W. Sanderson, Antonello Di Nardo, Wudu T. Jemberu, Nakarin Pamornchainavakul, Jonathan Arzt   +10 more
doaj   +1 more source

Characterization and Potential Utilizations of A Marine Euglenophyte from Okinawa, Japan

Squalen
mong many microalgae species, certain euglenophytes stand out as excellent sources of valuable natural components with diverse biotechnological applications.
Danang Ambar Prabowo, Shoichiro Suda
doaj   +1 more source