Results 161 to 170 of about 9,326,600 (310)

Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis. [PDF]

Circulation
Neyazi M, Venturini G, Brown KJ, Choi Y, Gorham JM, Layton OG, Verma A, Wang AJ, Gross RT, McDonough BA, Mendiola Pla M, Viveiros A, DeLaughter DM, DePalma SR, Kim Y, Reichart D, Wakimoto H, Elledge SJ, Divakaran S, Mitchell RN, Koh J, Park JB, Bowles DE, Glass C, Oudit GY, Seidman JG, Seidman CE.   +26 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Assessing the Effects of a 3-Dimensional (3D) Pathology Tissue-Processing Workflow on Downstream Molecular Analyses. [PDF]

Lab Invest
Baraznenok E, Hsieh HC, Lan L, Konnick EQ, Figiel S, Rao SR, Woodcock DJ, Mills IG, Hamdy FC, Valk JE, Carter KT, Yu M, Paulson TG, Dintzis S, Grady WM, Liu JTC.   +15 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The tapeworm species recorded in carnivores of Slovakian wildlife - molecular analyses. [PDF]

Front Vet Sci
Lazár J, Šmigová J, Šmiga L, Šnábel V, Syrota Y, Molnár L, Chabada M, Hančin M, Papajová I, Lazár P.   +9 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Phylogenetic Relationships and Genetic Diversity of Thai <i>Nepenthes</i> (Nepenthaceae) Revealed by Integrative Molecular Analyses. [PDF]

Plants (Basel)
Sontikun Y, Nuanlaong S, Böhnert T, Weigend M, Suraninpong P.   +4 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Cytokeratin Detection in Lymphoid Tumor Cell Lines: Implications for Flow Cytometry and Molecular Analyses. [PDF]

Cell Biol Int
Mizutani N, Takeuchi S, Koyanagi A, Hirano T, Kumagai Y, Okabe M, Asou K, Kido K, Kayano H, Shimazu Y, Ichikawa M, Kato R, Ito Y, Matsuoka S.   +13 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source