Results 171 to 180 of about 9,326,600 (310)

Integrative Phytochemical, Morphological and Molecular Analyses Reveal Intraspecific Diversification in Wild Iranian Populations of <i>Heracleum persicum</i> Desf. ex Fischer. [PDF]

Plants (Basel)
Rafiei SS, Mahdigholi K, Falahati-Anbaran M.   +2 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comprehensive molecular analyses for diagnosis and treatment guidance in an adult neuroblastoma patient. [PDF]

Oncologist
Rieke DT, Schwartz S, Ochsenreither S, Chapuy B, Amthauer H, Deubzer HE, Lehmann A, Keilholz U, Wardelmann E, Vokuhl C, Eggert A, Fröhling S, Horst D, Capper D, Keller U, Dragomir MP, Schallenberg S.   +16 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Co-Clinical Evaluation of Synthetic Vitamin D and Chemotherapy in Pancreatic Cancer by Integrated Imaging and Molecular Analyses. [PDF]

Cancer Res Commun
Gupta M, Choi H, Karasic T, Furth EE, Shaffer S, Englander S, Pickup S, Clendenin C, Liu F, Cao Q, Song HK, Fan Y, Duda J, Gee JC, Rosen M, O'Dwyer PJ, Zhou R.   +16 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integrative molecular analyses of lineage identity and morphology in aggressive variant prostate cancer. [PDF]

NPJ Precis Oncol
Li C, Yin J, Abel ML, Vargas Solivan DS, Bhadresha K, Kartal S, Nichols S, Parmar K, Twohig J, Truong TM, Chau CH, Kelly K, Figg WD, Thomas A, Sowalsky AG.   +14 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Safety and quality evaluation of commercial wheat flour in Saudi Arabia through microbiological, chemical, and molecular analyses: a preliminary baseline assessment. [PDF]

Front Microbiol
Khan Ghyathuddin AA, Al-Sarraj F, Bamagoos A, Nass NM, Mattar E, Baz A, Alotibi I, Shaibah A, Almatry MA, Al-Maaqar SM.   +9 more
europepmc   +1 more source