Results 151 to 160 of about 3,385,693 (328)

A noninvasive photoactivatable split-Cre recombinase system for genome engineering in zebrafish

iScience
Summary: The cyclic recombinase (Cre)/loxP recombination system is a powerful technique for in vivo cell labeling and tracking. However, achieving high spatiotemporal precision in cell tracking using this system is challenging due to the requirement for ...
Ramy Elsaid, Aya Mikdache, Patricia Diabangouaya, Gwendoline Gros, Pedro P. Hernández   +4 more
doaj  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Basic-helix-loop-helix family member e41 suppresses osteoclastogenesis and abnormal bone resorption disease via NFATc1

iScience
Summary: Overactivation of osteoclasts due to altered osteoclastogenesis causes multiple bone metabolic diseases. However, how osteoclast differentiation is tightly regulated and involved in multiple pathophysiological states remains mystery.
Yufeng Zhang, Xiaoguang Li, Jianlong Lang, Wenbo Li, Dengke Huang, Weizong Sun, Li Yang, Wenhui Li, Yi Wang, Liang Zhang   +9 more
doaj  

Molecular Biology: Dog Wags Tail [PDF]

, 1969

openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Novel requirements for HAP2/GCS1-mediated gamete fusion in Tetrahymena

iScience
Summary: The ancestral gamete fusion protein, HAP2/GCS1, plays an essential role in fertilization in a broad range of taxa. To identify factors that may regulate HAP2/GCS1 activity, we screened mutants of the ciliate Tetrahymena thermophila for behaviors
Jennifer F. Pinello, Josef Loidl, Ethan S. Seltzer, Donna Cassidy-Hanley, Daniel Kolbin, Anhar Abdelatif, Félix A. Rey, Rocky An, Nicole J. Newberger, Yelena Bisharyan, Hayk Papoyan, Haewon Byun, Hector C. Aguilar, Alex L. Lai, Jack H. Freed, Timothy Maugel, Eric S. Cole, Theodore G. Clark   +17 more
doaj  

Keratin and keratinization; an essay in molecular biology

, 1961
E. H. Mercer
openalex   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation

iScience
Summary: The Hippo signaling pathway is an important regulator of organ growth and differentiation, and its deregulation contributes to the development of cancer. The activity of its downstream targets YAP/TAZ depends on adherens junctions. Plakophilin 4
Lisa Müller, Tony Gutschner, Mechthild Hatzfeld   +2 more
doaj  

Vitamin C: Its Molecular Biology and Medical Potential [PDF]

, 1977
M.C. Scrutton
openalex   +1 more source