Molecular biology of brain aging and neurodegenerative disorders
, 1996 Thomas Wısnıewskı, Blas Frangione
openalex +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
BioSTEM: A modern educational tool for research and innovation in the field of molecular biology and personalized medicine. [PDF]
Hum GenomicsPatrinos GP +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Role of Renalase in Cardiovascular Disease: A Comprehensive Review of Its Molecular Biology, Genetic Associations, and Clinical Significance. [PDF]
Life (Basel)Dabravolski SA +5 more
europepmc +1 more source
MOLECULAR BIOLOGY APPROACH TO THE SEARCH FOR NOVEL HIV PROTEASES AND ANTIRETROVIRAL DRUGS
, 2004 G.O. Ifere, AB Utu-Baku
openalex +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
The TP53 tumor suppressor gene: From molecular biology to clinical investigations. [PDF]
J Intern MedBaliakas P, Soussi T.
europepmc +1 more source
WORLD OF REPRODUCTIVE BIOLOGY: Molecular Protector Shields Sperm from Death
, 2014 C. Schubert
openalex +1 more source