Results 1 to 10 of about 291,714 (118)

Frontiers in Molecular Neuroscience – Résumé and Perspective [PDF]

Frontiers in Molecular Neuroscience, 2011
Jochen Meier, Robert J Harvey
exaly   +2 more sources

BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

iScience, 2021
Summary: Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. However, the underlying molecular mechanism is incompletely understood.
Liansheng Zhang, Yun Qian, Jie Li, Xuan Zhou, He Xu, Jie Yan, Jialing Xiang, Xiang Yuan, Beicheng Sun, Sangram S. Sisodia, Yong-Hui Jiang, Xiaohua Cao, Naihe Jing, Anning Lin   +13 more
doaj   +1 more source

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation

iScience, 2023
Summary: SNARE-mediated membrane fusion plays a crucial role in presynaptic vesicle exocytosis and also in postsynaptic receptor delivery. The latter is considered particularly important for synaptic plasticity and learning and memory, yet the identity ...
Mengjia Huang, Na-Ryum Bin, Jayant Rai, Ke Ma, Chun Hin Chow, Sarah Eide, Hidekiyo Harada, Jianbing Xiao, Daorong Feng, Hong-Shuo Sun, Zhong-Ping Feng, Herbert Y. Gaisano, Jeffrey E. Pessin, Philippe P. Monnier, Kenichi Okamoto, Liang Zhang, Shuzo Sugita   +16 more
doaj   +1 more source

Molecular neuroscience: challenges ahead [PDF]

Frontiers in Neuroscience, 2008
Peter H Seeburg
doaj   +2 more sources

Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates

iScience, 2021
Summary: Rapid and efficient gene transduction via recombinant adeno-associated viruses (rAAVs) is highly desirable across many basic and clinical research domains.
Hongliang Gong, Nini Yuan, Zhiming Shen, Cheng Tang, Stewart Shipp, Liling Qian, Yiliang Lu, Ian Max Andolina, Shenghai Zhang, Jihong Wu, Hui Yang, Wei Wang   +11 more
doaj   +1 more source

The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines

iScience, 2023
Summary: Learning is thought to involve physiological and structural changes at individual synapses. Synaptic plasticity has predominantly been studied using regular stimulation patterns, but neuronal activity in the brain normally follows a Poisson ...
Ali Özgür Argunsah, Inbal Israely
doaj   +1 more source

Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models

iScience, 2021
Summary: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by reduced survival motor neuron (SMN) protein. Recently, SMN dysfunction has been linked to individual aspects of motor circuit pathology in a severe SMA mouse model.
Jannik M. Buettner, Josiane K. Sime Longang, Florian Gerstner, Katharina S. Apel, Beatriz Blanco-Redondo, Leonie Sowoidnich, Eva Janzen, Tobias Langenhan, Brunhilde Wirth, Christian M. Simon   +9 more
doaj   +1 more source

Structural basis for SARM1 inhibition and activation under energetic stress

eLife, 2020
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under stress conditions are still unknown. Here, we present
Michael Sporny, Julia Guez-Haddad, Tami Khazma, Avraham Yaron, Moshe Dessau, Yoel Shkolnisky, Carsten Mim, Michail N Isupov, Ran Zalk, Michael Hons, Yarden Opatowsky   +10 more
doaj   +1 more source

m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs

iScience, 2022
Summary: m6A modification plays an important role in regulating mammalian neurogenesis. However, whether and how the major cytoplasmic m6A readers, YTHDF1, YTHDF2, and YTHDF3 mediate this process is still not clear.
Fugui Niu, Pengfei Che, Zhuoxuan Yang, Jian Zhang, Lixin Yang, Mengru Zhuang, Xijun Ou, Sheng-Jian Ji   +7 more
doaj   +1 more source

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

iScience, 2023
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy   +7 more
doaj   +1 more source