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Molecular neuroscience: challenges ahead [PDF]

Frontiers in Neuroscience, 2008
A molecular neuroscientist with a pessimistic bent might feel that his field is coming to a close, seeing that most molecules contributing to a neuron's well-being and functional states are now known to us. There will still be unexplored ion channels and transcription factors in our genome, but isn't it merely a matter of time before these will be ...
Peter H Seeburg
doaj   +5 more sources

Frontiers in Molecular Neuroscience – Résumé and Perspective [PDF]

Frontiers in Molecular Neuroscience, 2011
The open access journal Frontiers in Molecular Neuroscience has existed since 2008. Publications started with an inaugural Research Topic centered on molecular mechanisms of the regulation of excitatory and inhibitory synapses in the brain – also known as E–I balance.
Jochen Meier, Robert J Harvey, Seeburg Peter H   +2 more
exaly   +5 more sources

The emergence of molecular systems neuroscience [PDF]

Molecular Brain, 2022
AbstractSystems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain states and behavior. Many of the studies in this field have traditionally involved electrophysiological recordings and computational approaches that attempt to decode how the brain transforms inputs ...
Shen, Yang, Luchetti, Alessandro, Fernandes, Giselle, Do Heo, Won, Silva, Alcino J   +4 more
openaire   +7 more sources

Editorial overview: Molecular neuroscience. [PDF]

Curr Opin Neurobiol, 2019
Ryan TA, Jin Y.
europepmc   +4 more sources

Editorial: Women in molecular neuroscience. [PDF]

Front Mol Neurosci
Žerovnik E.
europepmc   +4 more sources

BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

iScience, 2021
Summary: Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. However, the underlying molecular mechanism is incompletely understood.
Liansheng Zhang, Yun Qian, Jie Li, Xuan Zhou, He Xu, Jie Yan, Jialing Xiang, Xiang Yuan, Beicheng Sun, Sangram S. Sisodia, Yong-Hui Jiang, Xiaohua Cao, Naihe Jing, Anning Lin   +13 more
doaj   +1 more source

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation

iScience, 2023
Summary: SNARE-mediated membrane fusion plays a crucial role in presynaptic vesicle exocytosis and also in postsynaptic receptor delivery. The latter is considered particularly important for synaptic plasticity and learning and memory, yet the identity ...
Mengjia Huang, Na-Ryum Bin, Jayant Rai, Ke Ma, Chun Hin Chow, Sarah Eide, Hidekiyo Harada, Jianbing Xiao, Daorong Feng, Hong-Shuo Sun, Zhong-Ping Feng, Herbert Y. Gaisano, Jeffrey E. Pessin, Philippe P. Monnier, Kenichi Okamoto, Liang Zhang, Shuzo Sugita   +16 more
doaj   +1 more source

Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models

iScience, 2021
Summary: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by reduced survival motor neuron (SMN) protein. Recently, SMN dysfunction has been linked to individual aspects of motor circuit pathology in a severe SMA mouse model.
Jannik M. Buettner, Josiane K. Sime Longang, Florian Gerstner, Katharina S. Apel, Beatriz Blanco-Redondo, Leonie Sowoidnich, Eva Janzen, Tobias Langenhan, Brunhilde Wirth, Christian M. Simon   +9 more
doaj   +1 more source

Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates

iScience, 2021
Summary: Rapid and efficient gene transduction via recombinant adeno-associated viruses (rAAVs) is highly desirable across many basic and clinical research domains.
Hongliang Gong, Nini Yuan, Zhiming Shen, Cheng Tang, Stewart Shipp, Liling Qian, Yiliang Lu, Ian Max Andolina, Shenghai Zhang, Jihong Wu, Hui Yang, Wei Wang   +11 more
doaj   +1 more source

The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines

iScience, 2023
Summary: Learning is thought to involve physiological and structural changes at individual synapses. Synaptic plasticity has predominantly been studied using regular stimulation patterns, but neuronal activity in the brain normally follows a Poisson ...
Ali Özgür Argunsah, Inbal Israely
doaj   +1 more source