Results 21 to 30 of about 3,750,409 (253)

Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region

iScience, 2023
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal
Lujia Chen, Xiaoxiao Lin, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu   +6 more
doaj   +1 more source

Memory rescue and learning in synaptic impaired neuronal circuits

iScience, 2023
Summary: Neuronal impairment is a characteristic of Alzheimer’s disease (AD), but its effect on neural activity dynamics underlying memory deficits is unclear.
Kwan Tung Li, Daoyun Ji, Changsong Zhou
doaj   +1 more source

The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows

iScience
Summary: Animals constantly integrate sensory information with prior experience to select behavioral responses appropriate to the current situation. Genetic factors supporting this behavioral flexibility are often disrupted in neuropsychiatric conditions,
Rodrigo Zúñiga Mouret, Jordyn P. Greenbaum, Hannah M. Doll, Eliza M. Brody, Emma L. Iacobucci, Nicholas C. Roland, Roy C. Simamora, Ivan Ruiz, Rory Seymour, Leanne Ludwick, Jacob A. Krawitz, Antonia H. Groneberg, João C. Marques, Alexandre Laborde, Gokul Rajan, Filippo Del Bene, Michael B. Orger, Roshan A. Jain   +17 more
doaj   +1 more source

Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress

iScience, 2022
Summary: While schizophrenia pathogenesis involves both genetic and environmental factors, their specific combinations remain ill-defined. Here we show that deficiency in promoter VI-driven BDNF expression, combined with early-life adversity, results in ...
Yanhui Chen, Shangjin Li, Tianyi Zhang, Feng Yang, Bai Lu   +4 more
doaj   +1 more source

Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine

iScience, 2021
Summary: Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level.
Yeting Zeng, Huoqing Luo, Zilong Gao, Xiaona Zhu, Yinbo Shen, Yulong Li, Ji Hu, Jiajun Yang   +7 more
doaj   +1 more source

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

iScience
Summary: Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects
Lars Binkle-Ladisch, Andy Pironet, Andrea Zaliani, Chantal Alcouffe, Daniel Mensching, Undine Haferkamp, Anne Willing, Marcel S. Woo, Alexandre Erdmann, Timm Jessen, Stephen D. Hess, Philip Gribbon, Ole Pless, Rudi Vennekens, Manuel A. Friese   +14 more
doaj   +1 more source

Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation

iScience, 2019
Summary: Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorders (ASDs) in human genetic studies. Here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (PFC) of Shank3-deficient mice with ...
Luye Qin, Kaijie Ma, Zhen Yan
doaj   +1 more source

FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migrations

iScience, 2023
Summary: Mutations in the human fasciculation and elongation protein zeta 1 (FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during brain ...
Yinghua Qu, Jonathan Jun-Yong Lim, Omer An, Henry Yang, Yi-Chin Toh, John Jia En Chua   +5 more
doaj   +1 more source

ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling

iScience
Summary: Depression is a devastating mood disorder that causes significant disability worldwide. Current knowledge of its pathophysiology remains modest and clear biological markers are lacking.
Lluis Miquel-Rio, Unai Sarriés-Serrano, María Sancho-Alonso, Eva Florensa-Zanuy, Verónica Paz, Esther Ruiz-Bronchal, Sharon Manashirov, Leticia Campa, Fuencisla Pilar-Cuéllar, Analia Bortolozzi   +9 more
doaj   +1 more source

Semaphorin 6A–Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons

iScience, 2019
Summary: Precise regulation of neuronal migration termination is crucial for the establishment of brain cytoarchitectures. However, little is known about how neurons terminate migration.
Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata   +8 more
doaj   +1 more source