Results 21 to 30 of about 303,821 (302)

Multiscale Neuroscience of Psychiatric Disorders [PDF]

, 2019
The human brain comprises a multiscale network with multiple levels of organization. Neurons with dendritic and axonal connections form the microscale fabric of brain circuitry, and macroscale brain regions and white matter connections form the ...
van den Heuvel, Martijn, Scholtens, Lianne H, Kahn, Rene, van den Heuvel, Martijn P, Scholtens, Lianne, van den Heuvel, Martijn P., Scholtens, Lianne H., Scholtens, Lianne; id_orcid, Kahn, René S., Kahn, René S   +9 more
core   +1 more source

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

iScience, 2023
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy   +7 more
doaj   +1 more source

Of the Helmholtz Club, South-Californian seedbed for visual and cognitive neuroscience, and its patron Francis Crick [PDF]

, 2014
Taking up the view that semi-institutional gatherings such as clubs, societies, research schools, have been instrumental in creating sheltered spaces from which many a 20th-century project-driven interdisciplinary research programme could develop and ...
Aicardi, Christine, Aicardi, Christine; id_orcid, Aicardi, C   +2 more
core   +1 more source

The road ahead in clinical network neuroscience [PDF]

, 2019
Clinical network neuroscience, the study of brain network topology in neurological and psychiatric diseases, has become a mainstay field within clinical neuroscience.
van den Heuvel, Martijn, Senden, Mario, Hillebrand, Arjan, Senden, Mario; id_orcid, van Straaten, Elisabeth C.W., de Haan, Willem, Stam, Cornelis J., Nissen, Ida A., Tijms, Betty M., van Straaten, Elisabeth C. W., Griffa, Alessandra, Otte, Willem M., Reijmer, Yael D., van Dellen, Edwin, Tewarie, Prejaas, Gouw, Alida A., Douw, Linda, Van Mieghem, Piet, Schoonheim, Menno M.   +18 more
core   +1 more source

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System

iScience, 2020
Summary: Extracellular vesicles (EVs) are important mediators of intercellular communication. Interest in the role of central nervous system (CNS)-derived EVs has been increasing; however, some skepticism of their importance has persisted because many ...
David R. Graykowski, Yi-Zhi Wang, Arun Upadhyay, Jeffrey N. Savas   +3 more
doaj   +1 more source

Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway

iScience, 2022
Summary: The suprachiasmatic nucleus (SCN) integrates light and systemic signals from peripheral tissues to coordinate physiology and behavior daily rhythms.
Qiaocheng Zhai, Yizhun Zeng, Yue Gu, Zhihao Li, Tao Zhang, Baoshi Yuan, Tao Wang, Jie Yan, Han Qin, Ling Yang, Xiaowei Chen, Antonio Vidal-Puig, Ying Xu   +12 more
doaj   +1 more source

Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and Brain Damage after Reperfusion in Ischemic Stroke

iScience, 2020
Summary: Astrocytic glycogen is an important energy reserve in the brain and is believed to supply fuel during energy crisis. However, the pattern of glycogen metabolism in ischemic stroke and its potential therapeutic impact on neurological outcomes are
Yanhui Cai, Haiyun Guo, Ze Fan, Xinlei Zhang, Di Wu, Wenhong Tang, Tingting Gu, Shiquan Wang, Anqi Yin, Liang Tao, Xunming Ji, Hailong Dong, Yan Li, Lize Xiong   +13 more
doaj   +1 more source

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

iScience, 2021
Summary: Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer’s disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated.
Melanie Das, Wenjie Mao, Eric Shao, Soniya Tamhankar, Gui-Qiu Yu, Xinxing Yu, Kaitlyn Ho, Xin Wang, Jiaming Wang, Lennart Mucke   +9 more
doaj   +1 more source

The International Clinical Neuroscience Journal; 2022 in a Glance: A Work Overview for 2022 [PDF]

, 2023
The acceptance rate in the ICNJ was 46% (rejection rate: 54%) in 2022 and the average peer review time was around three weeks. Overall, 32 papers, including 16 (50%) original articles, 8 (25%) case reports, 6 (18.75%) review articles, and 2 (6.25 ...
Zali, Alireza, Akhlaghdoust, Meisam
core  

Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke

iScience, 2022
Summary: Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event, neuronal death is triggered by uncontrolled glutamate release leading to overactivation of glutamate sensitive N-methyl-d-aspartate receptor (NMDAR ...
Julia Cappelli, Pamela Khacho, Boyang Wang, Alexandra Sokolovski, Wafae Bakkar, Sophie Raymond, Nina Ahlskog, Julian Pitney, Junzheng Wu, Prakash Chudalayandi, Adrian Y.C. Wong, Richard Bergeron   +11 more
doaj   +1 more source