Results 21 to 30 of about 539,557 (301)
iScience, 2021 Summary: Rapid and efficient gene transduction via recombinant adeno-associated viruses (rAAVs) is highly desirable across many basic and clinical research domains.
Hongliang Gong +11 more
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iScience, 2023 Summary: Learning is thought to involve physiological and structural changes at individual synapses. Synaptic plasticity has predominantly been studied using regular stimulation patterns, but neuronal activity in the brain normally follows a Poisson ...
Ali Özgür Argunsah, Inbal Israely
doaj +1 more source
The emergence of molecular systems neuroscience [PDF]
Molecular Brain, 2022 AbstractSystems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain states and behavior. Many of the studies in this field have traditionally involved electrophysiological recordings and computational approaches that attempt to decode how the brain transforms inputs ...
Shen, Yang +4 more
openaire +5 more sources
m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs
iScience, 2022 Summary: m6A modification plays an important role in regulating mammalian neurogenesis. However, whether and how the major cytoplasmic m6A readers, YTHDF1, YTHDF2, and YTHDF3 mediate this process is still not clear.
Fugui Niu +7 more
doaj +1 more source
Structural basis for SARM1 inhibition and activation under energetic stress
eLife, 2020 SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under stress conditions are still unknown. Here, we present
Michael Sporny +10 more
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Mu-opioid receptor selective superagonists produce prolonged respiratory depression
iScience, 2023 Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm +7 more
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Unifying the essential concepts of biological networks: biological insights and philosophical foundations [PDF]
, 2020 Over the last decades, network-based approaches have become highly popular in diverse fields of biology, including neuroscience, ecology, molecular biology and genetics.
Hilgetag, Claus +2 more
core +2 more sources
Gain control in molecular information processing: Lessons from neuroscience [PDF]
, 2011 Statistical properties of environments experienced by biological signaling systems in the real world change, which necessitate adaptive responses to achieve high fidelity information transmission. One form of such adaptive response is gain control.
Berg H +6 more
core +1 more source
iScience, 2019 Summary: Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorders (ASDs) in human genetic studies. Here we found that chemogenetic activation of pyramidal neurons in the prefrontal cortex (PFC) of Shank3-deficient mice with ...
Luye Qin, Kaijie Ma, Zhen Yan
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The Dichotomous Role of Extracellular Vesicles in the Central Nervous System
iScience, 2020 Summary: Extracellular vesicles (EVs) are important mediators of intercellular communication. Interest in the role of central nervous system (CNS)-derived EVs has been increasing; however, some skepticism of their importance has persisted because many ...
David R. Graykowski +3 more
doaj +1 more source