Results 31 to 40 of about 3,929,505 (299)

Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region

iScience, 2023
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal
Lujia Chen, Xiaoxiao Lin, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu   +6 more
doaj   +1 more source

Neuroscience of alcoholism: molecular and cellular mechanisms [PDF]

Cellular and Molecular Life Sciences, 2009
Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of
Sachin, Moonat, Bela G, Starkman, Amul, Sakharkar, Subhash C, Pandey   +3 more
openaire   +2 more sources

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

iScience
Summary: Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects
Lars Binkle-Ladisch, Andy Pironet, Andrea Zaliani, Chantal Alcouffe, Daniel Mensching, Undine Haferkamp, Anne Willing, Marcel S. Woo, Alexandre Erdmann, Timm Jessen, Stephen D. Hess, Philip Gribbon, Ole Pless, Rudi Vennekens, Manuel A. Friese   +14 more
doaj   +1 more source

Semaphorin 6A–Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons

iScience, 2019
Summary: Precise regulation of neuronal migration termination is crucial for the establishment of brain cytoarchitectures. However, little is known about how neurons terminate migration.
Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata   +8 more
doaj   +1 more source

Memory rescue and learning in synaptic impaired neuronal circuits

iScience, 2023
Summary: Neuronal impairment is a characteristic of Alzheimer’s disease (AD), but its effect on neural activity dynamics underlying memory deficits is unclear.
Kwan Tung Li, Daoyun Ji, Changsong Zhou
doaj   +1 more source

The road ahead in clinical network neuroscience

, 2019
Clinical network neuroscience, the study of brain network topology in neurological and psychiatric diseases, has become a mainstay field within clinical neuroscience.
van den Heuvel, Martijn, Senden, Mario, Hillebrand, Arjan, Senden, Mario; id_orcid, van Straaten, Elisabeth C.W., de Haan, Willem, Stam, Cornelis J., Nissen, Ida A., Tijms, Betty M., van Straaten, Elisabeth C. W., Griffa, Alessandra, Otte, Willem M., Reijmer, Yael D., van Dellen, Edwin, Tewarie, Prejaas, Gouw, Alida A., Douw, Linda, Van Mieghem, Piet, Schoonheim, Menno M.   +18 more
core   +1 more source

Programmable DNA Nanodevices for Applications in Neuroscience

, 2021
The broad area of neuroscience has witnessed an increasing exploitation of a variety of synthetic biomaterials with controlled nanosized features. Different bionanomaterials offer very peculiar physicochemical and biochemcial properties contributing to ...
Hivare, Pravin, Panda, Chinmaya, Sharad Gupta, Gupta, Sharad, Pravin Hivare, Chinmaya Panda, Dhiraj Bhatia, Bhatia, Dhiraj   +7 more
core   +1 more source

Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress

iScience, 2022
Summary: While schizophrenia pathogenesis involves both genetic and environmental factors, their specific combinations remain ill-defined. Here we show that deficiency in promoter VI-driven BDNF expression, combined with early-life adversity, results in ...
Yanhui Chen, Shangjin Li, Tianyi Zhang, Feng Yang, Bai Lu   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine

iScience, 2021
Summary: Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level.
Yeting Zeng, Huoqing Luo, Zilong Gao, Xiaona Zhu, Yinbo Shen, Yulong Li, Ji Hu, Jiajun Yang   +7 more
doaj   +1 more source