Results 51 to 60 of about 3,929,505 (299)

Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma

iScience, 2023
Summary: Interactions between microglia and macroglia play important roles in the neurodegeneration of the central nervous system and so is the situation between microglia and Müller cells in retina neurodegenerations like glaucoma. This study focuses on
Huan Yu, Huimin Zhong, Jun Sun, Na Li, Junjue Chen, Bingqiao Shen, Ping Huang, Xi Shen, Shouyue Huang, Yisheng Zhong   +9 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Miami Neuroscience Institute - Fall 2020

, 2020
https://scholarlycommons.baptisthealth.net/bg-bh-neuroscience-news/1003/thumbnail ...
Miami Neuroscience Institute
core   +1 more source

Chronic modulation of cAMP signaling elicits synaptic scaling irrespective of activity

iScience
Summary: Homeostatic plasticity mechanisms act in a negative feedback manner to stabilize neuronal firing around a set point. Classically, homeostatic synaptic plasticity is elicited via rather drastic manipulation of activity in a neuronal population ...
Elena D. Bagatelas, Ege T. Kavalali
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Miami Neuroscience Institute - Summer 2020

, 2020
https://scholarlycommons.baptisthealth.net/bg-bh-neuroscience-news/1002/thumbnail ...
Miami Neuroscience Institute
core   +1 more source

Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism

iScience
Summary: Peripheral viral infection disrupts oligodendrocyte (OL) homeostasis such that endogenous remyelination may be affected. Here, we demonstrate that influenza A virus infection perpetuated a demyelination- and disease-associated OL phenotype ...
Allison Y. Louie, Jenny Drnevich, Jennifer L. Johnson, Meagan Woodard, Anna V. Kukekova, Rodney W. Johnson, Andrew J. Steelman   +6 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Experimentation in Cognitive Neuroscience and Cognitive Neurobiology [PDF]

, 2014
Neuroscience is a laboratory-based science that spans multiple levels of analysis from molecular genetics to behavior. At every level of analysis experiments are designed in order to answer empirical questions about phenomena of interest.
Sullivan, Jacqueline Anne, Jacqueline Sullivan   +1 more
core   +3 more sources

NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14

iScience
Summary: The blood-nerve-barrier (BNB) that regulates peripheral nerve homeostasis is formed by endoneurial capillaries and perineurial cells surrounding the Schwann cell (SC)-rich endoneurium.
Jennifer Patritti-Cram, Eric P. Rahrmann, Tilat A. Rizvi, Katherine C. Scheffer, Timothy N. Phoenix, David A. Largaespada, Nancy Ratner   +6 more
doaj   +1 more source