Results 51 to 60 of about 303,821 (302)

Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases [PDF]

, 2021
Functional genomics studies through transcriptomics, translatomics and proteomics have become increasingly important tools to understand the molecular basis of biological systems in the last decade. In most cases, when these approaches are applied to the
Sotelo-Silveira, José Roberto, Farias, Joaquina, Garat, Joaquin, Smircich, Pablo, Di Paolo, Andres, Eastman, Guillermo, Dajas-Bailador, Federico   +6 more
core   +2 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

iScience, 2021
Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the ...
Jie Zhang, Feng Gao, Yuqian Ma, Tian Xue, Yong Shen   +4 more
doaj   +1 more source

Journal of Neuroscience [PDF]

The nervous system contains complex circuits comprising thousands of cell types and trillions of connections. Here, we discuss how the field of "developmental systems neuroscience" combines the molecular and genetic perspectives of developmental ...
Dooley, James C., van der Heijden, Meike E.   +1 more
core   +1 more source

Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system [PDF]

, 2008
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons
Mac Gillavry, H.D., F. A. Court, W. T. J. Hendriks, van Minnen, J., H. D. MacGillavry, Minnen, J. van, J. Alvarez, J. van Minnen, Hendriks, W.T.J., Court, W.A., Van Winnen, J., Hendriks, W.T., Alvarez, J., Alvarez, J., Court, F.A., Macgillavry, H.D.   +15 more
core   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma

iScience, 2023
Summary: Interactions between microglia and macroglia play important roles in the neurodegeneration of the central nervous system and so is the situation between microglia and Müller cells in retina neurodegenerations like glaucoma. This study focuses on
Huan Yu, Huimin Zhong, Jun Sun, Na Li, Junjue Chen, Bingqiao Shen, Ping Huang, Xi Shen, Shouyue Huang, Yisheng Zhong   +9 more
doaj   +1 more source

Probing the brain with molecular fMRI [PDF]

, 2018
© 2018 Elsevier Ltd One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition.
Souparno Ghosh, Jacob C Simon, Peter Harvey, Harvey, Peter, Simon, Jacob Cyert, Ghosh, Souparno, Alan Jasanoff, Simon, Jacob C, Jasanoff, Alan   +8 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cytosolic dopamine determines hypersensitivity to blunt force trauma

iScience
Summary: The selective vulnerability of dopaminergic neurons to trauma-induced neurodegeneration is conserved across species, from nematodes to humans.
Kielen R. Zuurbier, Rene Solano Fonseca, Sonja L.B. Arneaud, Lexus Tatge, Gupse Otuzoglu, Jordan M. Wall, Peter M. Douglas   +6 more
doaj   +1 more source