Results 71 to 80 of about 303,821 (302)

Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism

iScience
Summary: Peripheral viral infection disrupts oligodendrocyte (OL) homeostasis such that endogenous remyelination may be affected. Here, we demonstrate that influenza A virus infection perpetuated a demyelination- and disease-associated OL phenotype ...
Allison Y. Louie, Jenny Drnevich, Jennifer L. Johnson, Meagan Woodard, Anna V. Kukekova, Rodney W. Johnson, Andrew J. Steelman   +6 more
doaj   +1 more source

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation. [PDF]

, 2014
The human molecular chaperone protein DNAJB6 was recently found to inhibit the formation of amyloid fibrils from polyglutamine peptides associated with neurodegenerative disorders such as Huntington's disease.
Knowles, Tuomas P J, Hussein, R., Boelens, Wilbert C., Linse, S., Emanuelsson, C., Mansson, C., Knowles, T.P., Dobson, C.M., Hashem, R.M., Dobson, Christopher M., Emanuelsson, Cecilia, Arosio, P., Månsson, Cecilia, Kampinga, Harm H, Boelens, Wilbert C, Arosio, Paolo, Kampinga, Harm H; id_orcid, Hashem, Reem M, Dobson, Christopher M, Hashem, Reem M., Kampinga, Harm H., Knowles, Tuomas P.J., Hussein, Rasha, Linse, Sara, Boelens, W.C., Kampinga, H.H.   +25 more
core   +1 more source

Why behavioral neuroscience still needs diversity? : A curious case of a persistent need [PDF]

, 2020
In the past few decades, a substantial portion of neuroscience research has moved from studies conducted across a spectrum of animals to reliance on a few species.
Vyas, Ajai, Mathuru, Ajay S., Teseo, Serafino, Libersat, Frédéric   +3 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14

iScience
Summary: The blood-nerve-barrier (BNB) that regulates peripheral nerve homeostasis is formed by endoneurial capillaries and perineurial cells surrounding the Schwann cell (SC)-rich endoneurium.
Jennifer Patritti-Cram, Eric P. Rahrmann, Tilat A. Rizvi, Katherine C. Scheffer, Timothy N. Phoenix, David A. Largaespada, Nancy Ratner   +6 more
doaj   +1 more source

The impact of molecular biology on neuroscience

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999
How our brains work is one of the major unsolved problems of biology. This paper describes some of the techniques of molecular biology that are already being used to study the brains of animals. Mainly as a result of the human genome project many new techniques will soon become available which could decisively influence the progress of neuroscience.
openaire   +3 more sources

A COMPREHENSIVE REVIEW ON UNRAVELLING THE INTRICACIES OF MOLECULAR NEUROSCIENCE [PDF]

<p>Molecular neuroscience is a multidisciplinary field dedicated to unravelling the molecular mechanisms underlying brain function and dysfunction.
Sri Laasya Tipparaju , Krishna Keerthika Oruganti , Laasya Priya Perumahanthi, Geethika Lakshmi Nimmagadda , Lakshmi Sravani Karangula, Siva Naga Mani Soma and Reethika Singh Ranwas   +2 more
core   +1 more source

Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]

, 2007
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J, Ernfors, P, Ernfors, P,, Koltzenburg, M, AlQatari, M   +4 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Mitochondrial methylcytosines as blood-based biomarkers for Alzheimer’s disease dementia prognosis

iScience
Summary: Alzheimer’s Disease Dementia (ADD) prognosis is an unmet medical need. Mitochondrial dysfunction is an early AD etiopathogenic factor. The present study analyzed mitochondrial DNA (mtDNA) methylation patterns in blood samples from patients with ...
Jordi Gascón-Bayarri, Jose Luis Mosquera, Marta Blanch, Pau Martí, Beatriz Fontal, Carla Trapero, Nuria Rojo, Inma Rico, Jaume Campdelacreu, Cristopher Fowler, Simon M. Laws, Adrià Tort-Merino, Raquel Sanchez-Valle, Joan Bello, Juan Fortea, Alberto Lleó, Courosh Mehanian, Russell H. Swerdlow, Ramón Reñé-Ramírez, Marta Barrachina   +19 more
doaj   +1 more source