Results 81 to 90 of about 3,929,505 (299)

Of Ethical Frameworks and Neuroethics in Big Neuroscience Projects : A View from the HBP

, 2020
The recently published BRAIN 2.0 Neuroethics Report offers a very helpful overview of the possible ethical, social, philosophical, and legal issues raised by neuroscience in the context of BRAIN’s research priorities thus contributing to the attempt to ...
Salles, Arleen, Farisco, Michele, Salles, Arleen,, Farisco, Michele,   +3 more
core   +1 more source

Founding Editorial: Neuro‐Drug Discovery

Neuro-Drug Discovery, EarlyView.
Wenbin Li
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

New observations in neuroscience using superresolution microscopy

, 2018
© 2018 the authors. Superresolution microscopy (SM) techniques are among the revolutionary methods for molecular and cellular observations in the 21st century.
Barna, László, Nozumi, Motohiro, Zhang, Mingshu, Xue, Fudong, Wu, Ling-Gang, Cella Zanacchi, Francesca, Xu, Pingyong, Igarashi, Michihiro, Katona, István, Boyden, Edward, Zhang M., Wu L. -G., Igarashi M., Katona X., Xue F., Xu P., Nozumi X., Boyden E., Cella Zanacchi F., Barna X. L.   +19 more
core   +1 more source

Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior

iScience, 2020
Summary: The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been ...
Ainhoa Bilbao, Daniela Neuhofer, Marja Sepers, Shou-peng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos-Uriarte, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J. Manzoni, Rainer Spanagel   +14 more
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina

iScience
Summary: Type 1 cannabinoid receptors (CB1Rs) are expressed in major retinal neurons within the rod-pathway suggesting a role in regulating night visual processing, but the underlying mechanisms remain poorly understood.
Sebastián F. Estay, Camila Morales-Moraga, Alex H. Vielma, Angelina Palacios-Muñoz, Chiayu Q. Chiu, Andrés E. Chávez   +5 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Can neuroscience construct a literate gendered culture? [PDF]

, 2011
The construction of boys as a gendered culture is not usually associated with neuroscience. Exceptions are publications and presentations by consultants on boys’ education who adopt a “brain-based” perspective.
Whitehead, David
core  

Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord

iScience
Summary: Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic locomotor behaviors remain unclear. This study investigated dopamine-induced episodic rhythms in isolated neonatal mouse spinal cords to understand these mechanisms ...
Jonathan J. Milla-Cruz, Adam P. Lognon, Michelle A. Tran, Stephanie A. Di Vito, Carlotta Löer, Anchita Shonak, Matthew J. Broadhead, Gareth B. Miles, Simon A. Sharples, Patrick J. Whelan   +9 more
doaj   +1 more source