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From Virtual Molecules to Clinical Trials: How AI Is Reshaping Preclinical Drug Discovery. [PDF]
J Med Internet ResCuffari B.
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Selecting a processor for computations in molecular biophysics
Computers in Biology and Medicine, 1988A number of relatively low-cost processors are now available which employ architectural features previously found only on very expensive supercomputers. The speed of these computers makes it possible to reduce the time to solution of certain problems and to resolve large problems that previously were too time consuming to perform locally.
Philip E Bourne +2 more
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Biophysical applications in structural and molecular biology
Biological Chemistry, 2021Abstract The main objective of structural biology is to model proteins and other biological macromolecules and link the structural information to function and dynamics. The biological functions of protein molecules and nucleic acids are inherently dependent on their conformational dynamics.
Solomon Tsegaye +2 more
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Hydration theory for molecular biophysics
2002Publisher Summary Protein stabilization by the presence of water may in part be a manifestation of hydration water destabilizing the unfolded state. This chapter presents a molecular theory of hydration that highlights the role of water in protein stabilization.
Michael E, Paulaitis, Lawrence R, Pratt
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, 2012 Biološki sustavi imaju strukturu i oblik, potrebna im je energija za gibanje u kojemu moraju očuvati svoj integritet, oni svojim oblikom i dinamikom moraju udovoljiti nizu fizikalnih zahtjeva. Ovi zahtjevi postavljaju se na skali veličine samog organizma, no budući da se struktura organizma izgrauje molekularno te da fizikalna svojstva materijala ...
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Methods in Molecular Biophysics
2007Our knowledge of biological macromolecules and their interactions is based on the application of physical methods, ranging from classical thermodynamics to recently developed techniques for the detection and manipulation of single molecules. These methods, which include mass spectrometry, hydrodynamics, microscopy, diffraction and crystallography ...
Igor N. Serdyuk +2 more
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Methods in Molecular Biophysics
2017Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including
Nathan R. Zaccai +2 more
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Biophysical and Molecular Targets
2013Cardiac arrhythmia is the leading cause of death in the Western world despite significant therapeutic improvements by surgical, interventional, and pharmacological approaches in the last decade. This chapter reviews the latest research in identifying drugs and targets with the aim of preventing the arrhythmia.
Mark Slevin +3 more
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Biophysics of Molecular Chaperones
2023Molecular chaperones are critical to control protein quality in all living cells. Understanding chaperone function at the atomic level, and in particular its mode of interaction with client proteins, is crucial to understanding the fundamental roles chaperones play in biology.
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