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Advanced Science, EarlyView.Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu +9 more
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Advanced Science, EarlyView.We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar +4 more
wiley +1 more source
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Selecting a processor for computations in molecular biophysics
Computers in Biology and Medicine, 1988A number of relatively low-cost processors are now available which employ architectural features previously found only on very expensive supercomputers. The speed of these computers makes it possible to reduce the time to solution of certain problems and to resolve large problems that previously were too time consuming to perform locally.
Philip E Bourne, Wayne A Hendrickson
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Biophysical applications in structural and molecular biology
Biological Chemistry, 2021Abstract The main objective of structural biology is to model proteins and other biological macromolecules and link the structural information to function and dynamics. The biological functions of protein molecules and nucleic acids are inherently dependent on their conformational dynamics.
Solomon Tsegaye +2 more
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Role of quantum chemical calculations in molecular biophysics with a historical perspective [PDF]
Theoretical Chemistry Accounts, 2009 We discuss how the basic principles of quantum chemistry and quantum mechanics can be and have been applied to a variety of problems in molecular biophysics. First, the historical development of quantum concepts in biophysics is discussed.
Kukushkin, A., Jalkanen, Karl
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Hydration theory for molecular biophysics
2002Publisher Summary Protein stabilization by the presence of water may in part be a manifestation of hydration water destabilizing the unfolded state. This chapter presents a molecular theory of hydration that highlights the role of water in protein stabilization.
Michael E, Paulaitis, Lawrence R, Pratt
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Methods in Molecular Biophysics
2007Our knowledge of biological macromolecules and their interactions is based on the application of physical methods, ranging from classical thermodynamics to recently developed techniques for the detection and manipulation of single molecules. These methods, which include mass spectrometry, hydrodynamics, microscopy, diffraction and crystallography ...
Igor N. Serdyuk +2 more
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, 2012 Biološki sustavi imaju strukturu i oblik, potrebna im je energija za gibanje u kojemu moraju očuvati svoj integritet, oni svojim oblikom i dinamikom moraju udovoljiti nizu fizikalnih zahtjeva. Ovi zahtjevi postavljaju se na skali veličine samog organizma, no budući da se struktura organizma izgrauje molekularno te da fizikalna svojstva materijala ...
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