Results 51 to 60 of about 146,944 (294)

ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer

International Journal of Cell Biology, 2012
It is commonly believed that sustained elevations in the mitochondrial matrix Ca2+ concentration are a major feature of the intracellular cascade of lethal events during cerebral ischemia.
Yi-Bing Ouyang, Rona G. Giffard
doaj   +1 more source

How do Chaperones Bind (Partly) Unfolded Client Proteins?

Frontiers in Molecular Biosciences, 2021
Molecular chaperones are central to cellular protein homeostasis. Dynamic disorder is a key feature of the complexes of molecular chaperones and their client proteins, and it facilitates the client release towards a folded state or the handover to ...
Iva Sučec, Beate Bersch, Paul Schanda, Paul Schanda   +3 more
doaj   +1 more source

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Craig, Elisabeth A., Herrmann, Johannes M., Neupert, Walter, Stuart, Rosemary A.   +3 more
core   +4 more sources

Redox-regulated molecular chaperones [PDF]

Cellular and Molecular Life Sciences, 2002
The conserved heat shock protein Hsp33 functions as a potent molecular chaperone with a highly sophisticated regulation. On transcriptional level, the Hsp33 gene is under heat shock control; on posttranslational level, the Hsp33 protein is under oxidative stress control.
Jakob, Ursula, Graf, Paul C. F.
openaire   +3 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal alpha-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma Predisposition [PDF]

, 2012
PMCID: PMC3534021This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Laenger, A Puga, A Raitila, AF Daly, AF Daly, AJ Perry, AP Heaney, B Bukau, B Panaretou, BD Hollingshead, C Prodromou, C Prodromou, C Scheufler, CA Leontiou, Chrisostomos Prodromou, CM Greiser, D Spengler, DR Bell, E Heliovaara, EB Krissinel, F Glaser, G Huang, G Siligardi, G Trivellin, GB Bolger, Giampaolo Trivellin, Giorgio Colombo, H Ashkenazy, HS Chahal, HS Chahal, HS Chahal, HS Feigelson, I Persson, IW Davis, JL Marlowe, LA Carver, LA Carver, Laura C. Hernández-Ramírez, LH Pearl, Lihong Zhou, M Fujimoto, M Landau, M Linnert, M Yano, M Zhang, MP Mayer, Márta Korbonits, N Kuzhandaivelu, O Vierimaa, P Emsley, P Pocar, PH Pang, PV Afonine, Q Zeng, Rhodri M. L. Morgan, S Igreja, S Safe, S. Mark Roe, SK de Oliveira, SK de Oliveira, SK Kolluri, W Cai, Z Ozfirat   +62 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The Neurochaperonopathies: Anomalies of the Chaperone System with Pathogenic Effects in Neurodegenerative and Neuromuscular Disorders

Applied Sciences, 2021
The chaperone (or chaperoning) system (CS) constitutes molecular chaperones, co-chaperones, and chaperone co-factors, interactors and receptors, and its canonical role is protein quality control.
Federica Scalia, Alessandra Maria Vitale, Radha Santonocito, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Methylglyoxal alters the function and stability of critical components of the protein quality control. [PDF]

PLoS ONE, 2010
BACKGROUND: Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes.
Carla Figueira Bento, Filipa Marques, Rosa Fernandes, Paulo Pereira   +3 more
doaj   +1 more source