Results 71 to 80 of about 7,940,505 (313)

Patient-derived and gene-edited pluripotent stem cells lacking NPHP1 recapitulate juvenile nephronophthisis in abnormalities of primary cilia and renal cyst formation

Frontiers in Cell and Developmental Biology
Juvenile nephronophthisis is an inherited renal ciliopathy with cystic kidney disease, renal fibrosis, and end-stage renal failure in children and young adults.
Yutaka Arai, Yutaka Arai, Hidenori Ito, Tomoya Shimizu, Tomoya Shimizu, Yuzuno Shimoda, Yuzuno Shimoda, Dan Song, Mami Matsuo-Takasaki, Tadayoshi Hayata, Yohei Hayashi, Yohei Hayashi   +11 more
doaj   +1 more source

Characterization and Molecular Identification of Poly Urethane Degrading Bacteria

Journal of Pure and Applied Microbiology, 2021
Plastics can be considered as the world’s largest pollution that is accumulating in the environment. The degradation of these plastics is difficult because they are accumulated over years and also they are dumped in an area which causes more ...
V. Shree Yazhini, M. Lakshmi Prabha, Reya Issac   +2 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Marigold Supercritical Extract as Potential Co-adjuvant in Pancreatic Cancer: The Energetic Catastrophe Induced via BMP8B Ends Up With Autophagy-Induced Cell Death

Frontiers in Bioengineering and Biotechnology, 2020
The recent development of powerful “omics” technologies (genomics, transcriptomics, proteomics, metabolomics, and lipidomics) has opened new avenues in nutritional sciences toward precision nutrition, which is a genotype-directed nutrition that takes ...
Marta Gómez de Cedrón, Lamia Mouhid, Elena García-Carrascosa, Tiziana Fornari, Guillermo Reglero, Guillermo Reglero, Ana Ramírez de Molina   +6 more
doaj   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source

Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts

BMC Complementary and Alternative Medicine, 2018
Background Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed.
Lamia Mouhid, Marta Gómez de Cedrón, Teodoro Vargas, Elena García-Carrascosa, Nieves Herranz, Mónica García-Risco, Guillermo Reglero, Tiziana Fornari, Ana Ramírez de Molina   +8 more
doaj   +1 more source

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Cell Reports, 2018
SUMMARY Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional “omic” data from The ...
Yumeng Wang, Xiaoyan Xu, Dejan Maglic, Michael T. Dill, K. Mojumdar, P. Ng, Kang Jin Jeong, Y. Tsang, D. Moreno, V. H. Bhavana, Xinxin Peng, Zhongqi Ge, Hu Chen, Jun Li, Zhongyuan Chen, Huiwen Zhang, Leng Han, Di Du, Chad J. Creighton, Gordon B. Mills, F. Camargo, Han Liang   +21 more
semanticscholar   +1 more source

Re‐Irradiation in Pediatric Diffuse Midline Glioma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with recurrent diffuse midline gliomas (DMGs) have limited therapeutic options at recurrence. Re‐irradiation (RT2) may be used at progression, but with uncertainty about the benefit. Methods We conducted a multi‐institutional retrospective study of children aged < 18 with DMG treated at three centers (Toronto, Canada ...
Ajay Thomas Alex, Sean P. Hassan, Helen Benghiat, Liam Herbert, Jennifer Adamski, Shivani Bailey, Claire Esler, Louise Brookes, Molly Bamber, Grace Koudou, Karen Waite, Julie Bennett, Anirban Das, Derek S. Tsang   +13 more
wiley   +1 more source

Clinical and molecular characterization of early‐onset colorectal cancer

Cancer, 2019
Colorectal cancer (CRC) incidence is increasing in adults younger than 50 years. This study evaluated clinical and molecular features to identify those features unique to early‐onset CRC that differentiate these patients from patients 50 years old or ...
Alexandra N. Willauer, Yusha Liu, A. Pereira, Michael Lam, Jeffrey S. Morris, K. Raghav, V. Morris, D. Menter, R. Broaddus, F. Meric-Bernstam, A. Hayes-Jordan, W. Huh, M. Overman, S. Kopetz, J. Loree   +14 more
semanticscholar   +1 more source

Molecular Characterization of a Caprine Adenovirus

Intervirology, 1996
Restriction endonuclease site maps were constructed for the genome of a caprine adenovirus (GAdV), strain NC90-7261, which was isolated in 1990 from a 3-year-old goat with encephalitis. Genomic GAdV DNA was digested with seven restriction endonucleases (RE).
E L, Williams, S B, Kleiboeker, P G, Reddy, D F, Clouser, H D, Lehmkuhl   +4 more
openaire   +2 more sources