Results 151 to 160 of about 3,939,990 (297)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Reflections on human cloning

open access: yes, 1999
Symposium On Human Cloning: Legal, Social, and Moral Perspectives for the Twenty-First ...
Solomon, Lewis D.
core  

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase

open access: yes, 1999
Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 ...
XY Zhu (16081796)   +6 more
core  

Molecular Cloning of the Acetylcholine Receptor

open access: yesCold Spring Harbor Symposia on Quantitative Biology, 1983
J, Patrick   +9 more
openaire   +2 more sources

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