Results 111 to 120 of about 62,910 (265)

Discovery of Multiple Ultra-broad-velocity Molecular Features Associated with the W44 Molecular Cloud

The Astrophysical Journal Letters
We report the discovery of multiple compact molecular features exhibiting extremely broad velocity widths toward the W44 molecular cloud. Atacama Large Millimeter/submillimeter Array CO J = 3–2 data reveal eight “Petit-Bullets” surrounding the previously
Momoko Makita, Tomoharu Oka, Shiho Tsujimoto, Tatsuya Kotani   +3 more
doaj   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Cloud Collision Signatures in the Central Molecular Zone

The Open Journal of Astrophysics
Molecular cloud collisions are a prominent theory for the formation of stars. Observational studies into cloud collisions identify the collision via a bridging feature: a continuous strip of line emission that connects two intensity peaks that are ...
Rees A. Barnes, Felix D. Priestley
doaj   +1 more source

Potassium isotope anomalies in meteorites inherited from the protosolar molecular cloud. [PDF]

Sci Adv, 2020
Ku Y, Jacobsen SB.
europepmc   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Missing interstellar sulfur in inventories of polysulfanes and molecular octasulfur crowns

Nature Communications
The disparity between predicted sulfur abundances and identified reservoirs of sulfur in cold molecular clouds, also known as the sulfur depletion problem, has remained an ongoing debate over decades.
Ashanie Herath, Mason McAnally, Andrew M. Turner, Jia Wang, Joshua H. Marks, Ryan C. Fortenberry, Jorge C. Garcia-Alvarez, Samer Gozem, Ralf I. Kaiser   +8 more
doaj   +1 more source

Oxygen isotopic heterogeneity in the early Solar System inherited from the protosolar molecular cloud. [PDF]

Sci Adv, 2020
Krot AN, Nagashima K, Lyons JR, Lee JE, Bizzarro M.   +4 more
europepmc   +1 more source

Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47

Advanced Science, EarlyView.
Dimethylsulfoniopropionate (DMSP) is a major marine organosulfur compound central to climate‐relevant dimethyl sulfide (DMS) production. In Halomonas sp. D47, DMSP catabolism is revealed to be coordinated by two transcriptional regulators, AcuR and AcuZ, which control gene expression by sensing DMSP and its metabolites.
Li‐Yuan Zheng, Wen‐Xin Jiang, Xiao‐Meng Sun, Li Liu, Zhao‐Jie Teng, Hou‐Qi Wang, Wen‐Jing Zhu, Chang Ge, Qi‐Long Qin, Ning‐Hua Liu, Hai‐Yan Cao, Hui‐Hui Fu, Chun‐Yang Li, Jonathan D. Todd, Xiu‐Lan Chen, Yu‐Zhong Zhang, Peng Wang   +16 more
wiley   +1 more source

3D MC. II. X-Ray Echoes Reveal a Clumpy Molecular Cloud in the CMZ

The Astronomical Journal
X-ray observations collected over the past decades have revealed a strongly variable X-ray signal within the Milky Way’s Galactic center, interpreted as X-ray echoes from its supermassive black hole, Sgr A*.
Danya Alboslani, Cara Battersby, Samantha W. Brunker, Maïca Clavel, Dani Lipman, Daniel L. Walker   +5 more
doaj   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source