Geometric Deep Learning-Based Drug Design Models for Small-Molecule Drug Discovery. [PDF]
Mol InformSrivastav AK +4 more
europepmc +1 more source
Advanced Science, EarlyView.This work presents a multifunctional ionic liquid, [SO3H‐PMIm][OTf], that addresses A‐site cation inhomogeneity and lead toxicity in pure‐iodide wide‐bandgap perovskite solar cells. The additive enables homogeneous cation distribution, achieving 22.02% efficiency with 90% retention after 3000 h and reducing lead leakage by over 58%, thereby ...
Kai Wu +8 more
wiley +1 more source
Quick communication: Active surveillance of rat sarcoma viral oncogene homolog-positive indeterminate thyroid nodules with categories III and IV, the Bethesda System for Reporting Thyroid Cytopathology, in thyroidology for thyroidologists. [PDF]
Rev Assoc Med Bras (1992)Sengul I, Sengul D.
europepmc +1 more source
MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation
Advanced Science, EarlyView.We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui +18 more
wiley +1 more source
Advanced Science, EarlyView.Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin +5 more
wiley +1 more source
An electron-density point-cloud framework for robust protein-ligand interaction prediction. [PDF]
Nat CommunLiu Y +9 more
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Non‐Covalent Reversibly Photoconvertible Fluorescent Tags for Wash‐Free Protein Labeling
Advanced Science, EarlyView.FAST proteins combined with one or two fluorogens undergo reversible fluorescence switching or photoconversion through photoisomerization. At low fluorogen concentration and high light intensity, they act as negative or positive photoswitchers and photoconvertible tags, which are promising for discriminating FAST variants.
Mrinal Mandal +12 more
wiley +1 more source
An Agent-Based Model of the Stellar Mass Distribution. [PDF]
Entropy (Basel)Olguín-Rodríguez ER +2 more
europepmc +1 more source
Advanced Science, EarlyView.A dual‐randomness hardware platform is demonstrated by integrating PUF and TRNG functionalities into mixed‐ZGO nanoclusters. By leveraging spatial and temporal stochasticity, the mixed‐ZGO NCs device enables both unique identification and random signal generation.
Seungme Kang +6 more
wiley +1 more source
ESpma: A method for assessing biological/non-biological interfaces using point-clouds-based structural features and protein language models. [PDF]
Protein SciNozawa S, Tomii K, Fukasawa Y.
europepmc +1 more source