Results 261 to 270 of about 139,100 (329)

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

Rotation measures of extragalactic radio sources viewed through the molecular clouds Cepheus A and L1551

, 1986
J. H. Simonetti, J. M. Cordes
openalex   +1 more source

From Code to Life: The AI‐Driven Revolution in Genome Editing

Advanced Science, EarlyView.
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li, Wasi Ullah Khan, Genxiang Bai, Chao Dong, Jungang Wang, Youpeng Zhang, Chong Wang, Hongbin Zhang, Wenyi Wang, Ming Luo, Fei Chen   +10 more
wiley   +1 more source

More π, please: What drives the formation of unsaturated molecules in the interstellar medium? [PDF]

Chem Sci
Londoño-Restrepo J, Gómez S, Quitián-Lara HM, Fantuzzi F, Restrepo A.   +4 more
europepmc   +1 more source

Unassisted Switchable Dual‐Photoelectrode Devices Utilizing p‐n Carbon Quantum Dots as “Semiconductor Electrolytes”: Optimization Between H2O2 and Solar Electricity Production

Advanced Science, EarlyView.
p‐n type carbon quantum dots (N‐CQDs) are designed as a conceptually‐new “semiconductor electrolyte” to develop a self‐driven photoelectrochemical cell that can be switched to optimize between H2O2 production and electricity generation under visible‐light illumination with water and O2 as reaction reagents.
Hui‐Min Duan, Chen‐Guang Li, Liu‐Meng Mo, Jing‐Shuang Dang, Xiao‐Hui Jia, Jia‐Cheng Yu, Yu‐Hang Mei, Anders Thapper, Hong‐Yan Wang   +8 more
wiley   +1 more source

Benchmarking the robustness of the correct identification of flexible 3D objects using common machine learning models. [PDF]

Patterns (N Y)
Zhang Y, Vitalis A.
europepmc   +1 more source

The NGC 2264 molecular cloud - Ammonia and OH observations

, 1980
K. R. Lang, R. F. Willson
openalex   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Faithful Interpretation of Protein Structures through Weighted Persistent Homology Improves Evolutionary Distance Estimation. [PDF]

Mol Biol Evol
Bou Dagher L, Madern D, Malbos P, Brochier-Armanet C.   +3 more
europepmc   +1 more source

Atomic Layered ZnO Between Cu Nanoparticles and a PVP Polymer Layer Enable Exceptional Selectivity and Stability in Electrocatalytic CO2 Reduction to C2H4

Advanced Science, EarlyView.
Collaboration between Cu, ZnO, and PVP facilitates the electrochemical reduction of CO2. Abstract This study employs a chemically controlled strategy to construct a few‐atomic‐layer ZnO structure integrated with polyvinylpyrrolidone (PVP) and nanoscale metallic copper on active carbon.
Lihui Zhou, Hung‐Wei Tsai, Ting‐Wei Kuo, Jui‐Cheng Kao, Yu‐Chieh Lo, Ji‐Min Chang, Tzu‐Hsuan Chiang, Sheng Dai, Kuan‐Wen Wang, Tsan‐Yao Chen   +9 more
wiley   +1 more source