Results 241 to 250 of about 3,978,643 (305)
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Pocket contrastive learning and conformation fusion for robust structure-conditioned 3D molecular generation under receptor conformational variation. [PDF]
BioinformaticsLiu H, Ding Y, Guo X, Wu H.
europepmc +1 more source
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Molecular Conformation of Inosine
Nature, 1969INOSINE is one of the rare nucleosides found in nucleic acids. It occurs especially in transfer ribonucleic acid where it appears to form part of a number of anticodons1,2. It can form a base pair with any one of the bases adenine, uracil or cytidine in the third codon1,2 position, and the possibility of atypical base pairs is part of the “wobble ...
P, Tollin, A R, Munns
openaire +2 more sources
Molecular Conformation of GABA
Nature New Biology, 1971CURTIS et al.1,2 have described evidence suggesting that the alkaloid bicuculline is a specific antagonist to the action of γ-aminobutyric acid (GABA), a possible inhibitory transmitter in the mammalian brain3,4. By considering structural models, they suggested3 as a stereochemical basis for this antagonism a geometrical configuration in which the N ...
E G, Steward +4 more
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Molecular Conformation of Deoxyuridine
Nature, 1971THE structure determination of deoxyuridine was undertaken as part of a series of conformational studies of nucleic acid components. Such studies give information about the preferred conformation of nucleosides and nucleotides1,2, and may clarify the conformational differences and changes that occur in nucleic acids.
A, Rahman, H R, Wilson
openaire +2 more sources