Results 161 to 170 of about 4,091,521 (342)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

SNARER: new molecular descriptors for SNARE proteins classification. [PDF]

BMC Bioinformatics, 2022
Auriemma Citarella A, Di Biasi L, Risi M, Tortora G.   +3 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

From Molecular Descriptors to Intrinsic Fish Toxicity of Chemicals: An Alternative Approach to Chemical Prioritization. [PDF]

Environ Sci Technol, 2023
Samanipour S, O'Brien JW, Reid MJ, Thomas KV, Praetorius A.   +4 more
europepmc   +1 more source

Prediction of Henry's law constant of CO2 in ionic liquids based on SEP and Sσ-profile molecular descriptors

, 2018
Xuejing Kang, Chunjiang Liu, Shaojuan Zeng, Zhijun Zhao, Jianguo Qian, Yongsheng Zhao   +5 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

On Some Properties of Fuzzy Topological Indices of Honeycomb Graph

Journal of Mathematics
The primary contribution of this paper is the characterization of a novel graph structure, the fuzzy honeycomb network, through the lens of fuzzy molecular descriptors.
Sana Shafqat, Naveed Yaqoob, Aliya Javed
doaj   +1 more source

Fusing 2D and 3D molecular graphs as unambiguous molecular descriptors for conformational and chiral stereoisomers. [PDF]

Brief Bioinform, 2023
Du W, Yang X, Wu D, Ma F, Zhang B, Bao C, Huo Y, Jiang J, Chen X, Wang Y.   +9 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Novel descriptors for the prediction of molecular properties

Open Chemistry
Molecular descriptors are fundamental to the fields of cheminformatics, drug discovery, and materials science, serving as quantitative representations of molecular structures that facilitate the prediction of various properties and activities.
Nizami Abdul Rauf, Ali Sayyada Fiza, Afzal Muhammad Zia, Inc Mustafa   +3 more
doaj   +1 more source