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Directed Molecular Evolution

Origins of life and evolution of the biosphere, 1999
We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutionary constraints on the DNA sequences themselves, thus retaining these sequences and governing the ...
L F, Harris   +2 more
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Molecular evolution in bacteria

Antonie van Leeuwenhoek, 1995
Recent advances in microbiology and molecular biology have a unifying influence on our understanding of genetic diversity/similarity and evolutionary relationships in microorganisms. This article attempts to unify information from diverse areas such as microbiology, molecular biology, microbial physiology, clay crystal genes, metals-microbe-clay ...
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Molecular insights into evolution

Artificial Life and Robotics, 1999
The evolution of ribonucleic acid (RNA) molecules in the test tube provides a possible way to study evolutionary optimization and adaptation to the environment on time scales accessible to human observers. Diversity of genotypes, however, is prohibitive for a complete experimental recording of the process at the molecular level.
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Molecular Evolution of Leptin

General and Comparative Endocrinology, 2001
Leptin, a hormone produced mainly by adipocytes, is involved in the regulation of food intake, metabolism, and reproduction. The objective of this study was to determine the evolutionary relationships of leptin genes. Partial nucleotide sequences of leptin were cloned and sequenced from six mammalian species: large hairy armadillo (Chaetophractus ...
C, Doyon   +3 more
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The molecular evolution of development

BioEssays, 1998
Morphological differences between species, from simple single-character differences to large-scale variation in body plans, can be traced to changes in the timing and location of developmental events. This has led to a growing interest in understanding the genetic basis behind the evolution of developmental systems.
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The molecular evolution of trypanosomatidae

2001
In the absence of a fossil record, theories relating to the evolution of protozoa have, for most of the twentieth century, been based on morphological and life cycle data despite their known limitations. However, recent advances in molecular methodology, notably the wide availability of accurate, automated DNA sequencing, have made it possible to ...
J R, Stevens   +3 more
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Molecular Evolution of hisB Genes

Journal of Molecular Evolution, 2004
The sixth and eighth steps of histidine biosynthesis are catalyzed by an imidazole glycerol-phosphate (IGP) dehydratase (EC 4.2.1.19) and by a histidinol-phosphate (HOL-P) phosphatase (EC 3.1.3.15), respectively. In the enterobacteria, in Campylobacter jejuni and in Xylella/Xanthomonas the two activities are associated with a single bifunctional ...
M. Brilli, FANI, RENATO
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Rates of Molecular Evolution

Annual Review of Ecology and Systematics, 1986
Many patterns in the evolution of proteins and DNA are now well established and have been adequately reviewed in recent years (23, 37, 38, 52, 55, 61, 73). However, there are several gaps in our understanding of the process of molecular evolution, the most conspicuous of which is our ignorance of the forces responsible for most of the evolution of DNA ...
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Applied molecular evolution

Journal of Theoretical Biology, 1992
The exciting results published by Scott & Smith (1990), Devlin et al. (1990), and Tuerk & Gold (1990) in Science; Cwirla et al., in the Proceedings of the National Academy of Sciences of the U.S.A. (1990) ; and Ellington & Szostak in Nature, London (1990), are the next developments in a new era in biotechnology: applied molecular evolution.
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Molecular Evolution of Proteasomes

2002
Proteasomes are large, multisubunit proteases that are found, in one form or another, in all domains of life and play a critical role in intracellular protein degradation. Although they have substantial structural similarity, the proteasomes of bacteria, archaea, and eukaryotes show many differences in architecture and subunit composition. This article
Volker, C.   +1 more
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