Results 91 to 100 of about 5,499,417 (372)

Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response [PDF]

, 2009
Dramatic rise of mutators has been found to accompany adaptation of bacteria in response to many kinds of stress. Two views on the evolutionary origin of this phenomenon emerged: the pleiotropic hypothesis positing that it is a byproduct of environmental
A Giraud, A Sali, AC Shaver, B Li, CS Wylie, DK Klimov, E Dekel, E Denamur, E Denamur, E Shakhnovich, E Shakhnovich, EI Shakhnovich, EI Shakhnovich, EJ Deeds, ES Slechta, Eugene I. Shakhnovich, F Taddei, G Feng, GM Suel, HC Tsui, I Bjedov, I Matic, IN Berezovsky, JAGM de Visser, JB Andre, JD Bloom, JM Raser, JW Drake, KB Zeldovich, KB Zeldovich, KB Zeldovich, KK Yan, KL Huisinga, KP Bjornson, L Lopez-Maury, M Heo, M Wrande, MB Elowitz, MJ Schofield, ML Mendillo, Muyoung Heo, N Rosenfeld, O Tenaillon, O Tenaillon, PD Sniegowski, PD Sniegowski, PJ Gerrish, PL Foster, R Du, RE Lenski, RR Iyer, RS Galhardo, RS Harris, Rustom Antia, S Maslov, S Miyazawa, WA Rosche, WJ Blake   +57 more
core   +5 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Molecular genetics of cataract.

Indian Journal of Ophthalmology, 2000
Studies on hereditary congenital cataracts have led to the identification of genes involved in formation of these cataracts. Knowledge of the structure and function of a particular gene and the effect of disease-associated mutations on its function are ...
Kannabiran Chitra, Balasubramanian D.
doaj  

Assessing structure-function impacts on Vitellogenin by leveraging allelic variant found in honey bee subspecies Apis mellifera mellifera

iScience
Summary: Advances involving artificial intelligence (AI) and experimental structure determination can provide detailed pictures of complex protein structures and their variations.
Vilde Leipart, Oriol Gracia Carmona, Christine Orengo, Franca Fraternali, Gro V. Amdam   +4 more
doaj   +1 more source

Editorial: Yeast cell aging and death [PDF]

, 2018
A conspicuous amount of knowledge about the molecular biol- ogy of the cell has come from studies on yeast Saccharomyces cere- visiae, mostly because of its unrivaled qualities as a toolkit for molecular genetics study.
Cristina Mazzoni, Sergio Giannattasio
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Simple and highly specific targeting of resident microglia with adeno-associated virus

iScience
Summary: Microglia, as the immune cells of the central nervous system (CNS), play dynamic roles in both healthy and diseased conditions. The ability to genetically target microglia using viruses is crucial for understanding their functions and advancing ...
Carolina Serrano, Sergio Cananzi, Tianjin Shen, Lei-Lei Wang, Chun-Li Zhang   +4 more
doaj   +1 more source

Gene expression drives the evolution of dominance. [PDF]

, 2018
Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits.
A Durvasula, A Platt, AF Agrawal, B Charlesworth, BM Henn, BY Kim, CD Huber, CD Huber, D Enard, D Ortega-Del Vecchyo, D Szklarczyk, DJ Balick, F Gao, F Manna, FH Shaw, H Kacser, HA Orr, I Frumkin, J Yang, JBS Haldane, JS Sanjak, KE Lohmueller, KM Teshima, LD Hurst, MA DePristo, MJ Simmons, N Phadnis, P Cingolani, P Lamesch, PY Novikova, RA Fisher, RD Hernandez, RN Gutenkunst, S Glémin, S Ossowski, S Williamson, S Wright, SH Williamson, T Bedford, T Kawakatsu, T Mukai, TI Gossmann, TT Hu, X Zheng, YB Simons   +44 more
core   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Interview with Huda Zoghbi [PDF]

, 2016
An oral history interview with Dr. Huda Zoghbi about her career at Baylor College of Medicine in the Texas Medical Center. She worked as a professor in the Departments of Pediatrics, Molecular and Human Genetics, Neurology and Neuroscience at Baylor ...
Zoghbi, Huda, MD
core   +1 more source