Results 71 to 80 of about 939,325 (312)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The scale of population structure in Arabidopsis thaliana [PDF]

, 2010
The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow.
Mulyati, N.W., Platt, A., Nordborg, M., Huang, Y.S., Luz Rivero, Mulyati, N., Li, Y., Bergelson, J, Eric B Holub, Anastasio, Alison E., Warthmann, N., Borevitz, J. O., Hudson, Andrew, Platt, Alexander, Donohue, Kathleen, Ph.D., Holub, Eric B., Byers, Diane, Ni Wayan Mulyati, Anastasio, A., Byers, D., Valérie Le Corre, Donohue, Kathleen, Justin O Borevitz, Holub, Eric B, Horton, M., Alison E Anastasio, Anastasio, Alison E, Dunning, M, Rivero, L, Holub, E., Bossdorf, O, Borevitz, J., Agren, J., Randy Scholl, Nordborg, M, Huang, Y. S., Loudet, Olivier, Roux, Fabrice, Scholl, Randy, Mulyati, N. W., Alexander Platt, Weigel, Detlaf, Loudet, O., Le Corre, V, Hudson, A., Huang, Yu S, Borevitz, J.O., Bossdorf, O., Holub, E, Ågren, Jon, Loudet, O, Magnus Nordborg, Roux, F., Warthmann, Norman, Diane Byers, Horton, Matthew, Scholl, R, Anastasio, A. E., Borevitz, Justin O, Scholl, R., Anastasio, Alison Elizabeth, Borevitz, Justin O., Rivero, L., Huang, Y., Anastasio, A, Matthew Horton, Borevitz, JO, Ågren, Jon,, Platt, A, Hudson, A, Bossdorf, Oliver, Horton, M, Agren, J, Anastasio, A.E., Platt, A. (Alexander), Olivier Loudet, Le Corre, V., Weigel, D., Donohue, K, Le Corre, Valérie, Nordborg, Magnus, Byers, D, Holub, E.B., Li, Yan, Kathleen Donohue, Holub, E. B., Fabrice Roux, Dunning, M., Hudson, A. (Andrew), Andrew Hudson, Yan Li, Norman Warthmann, Mulyati, W, Li, Y. (Yan), Huang, Yu S., Dunning, Megan, Huang, Y, Jon Agren, Detlef Weigel, Bergelson, Joy, Mulyati, Ni Wayan, Oliver Bossdorf, Bergelson, J., Joy Bergelson, Rivero, Luz, Weigel, Detlef, Donohue, K., Li, Y, Megan Dunning, Yu S Huang   +109 more
core   +1 more source

Molecular genetics of cataract.

Indian Journal of Ophthalmology, 2000
Studies on hereditary congenital cataracts have led to the identification of genes involved in formation of these cataracts. Knowledge of the structure and function of a particular gene and the effect of disease-associated mutations on its function are ...
Kannabiran Chitra, Balasubramanian D.
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Beyond Theoretical Reduction and Layer-Cake Antireduction: How DNA Retooled Genetics and Transformed Biological Practice [PDF]

, 2008
Watson and Crick’s discovery of the structure of DNA led to developments that transformed many biological sciences. But what were the relevant developments and how did they transform biology?
Waters, C. Kenneth
core  

Assessing structure-function impacts on Vitellogenin by leveraging allelic variant found in honey bee subspecies Apis mellifera mellifera

iScience
Summary: Advances involving artificial intelligence (AI) and experimental structure determination can provide detailed pictures of complex protein structures and their variations.
Vilde Leipart, Oriol Gracia Carmona, Christine Orengo, Franca Fraternali, Gro V. Amdam   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Simple and highly specific targeting of resident microglia with adeno-associated virus

iScience
Summary: Microglia, as the immune cells of the central nervous system (CNS), play dynamic roles in both healthy and diseased conditions. The ability to genetically target microglia using viruses is crucial for understanding their functions and advancing ...
Carolina Serrano, Sergio Cananzi, Tianjin Shen, Lei-Lei Wang, Chun-Li Zhang   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source