Results 61 to 70 of about 53,853 (212)

Molecular genetics of suicide

Zdravniški Vestnik, 2006
Background: Suicide is a complex phenomenon that is triggered by environmental factors, and probably partially also by genetic code. Genetic studies performed on suicide brain contributed interesting findings on serotonergic, dopaminergic and ...
Alja Videtič, Galina Pungerčič
doaj  

The molecular genetics of the dystonias [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1998
Since the introduction of the term dystonia by Oppenheim in 1911 to describe altering muscle tone and postural deformities seen in patients,1 there has been considerable controversy surrounding its aetiology, classification, and genetics. Dystonia can describe a symptom, a syndrome, or a clinical sign that is part of a more severe neurological disorder.
T T, Warner, P, Jarman
openaire   +2 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Immunoglobulin Depletion and Recovery Following Blinatumomab in Infants With KMT2A‐Rearranged ALL

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Adding blinatumomab to standard chemotherapy for infants with KMT2A‐rearranged acute B‐cell lymphoblastic leukemia (KMT2A‐r B‐ALL) improves outcomes. Although blinatumomab impairs immunoglobulin G (lgG) production, increasing infection susceptibility, IgG recovery remains poorly understood.
Miguel Vieira Martins, Paola de Lorenzo, Rishi S. Kotecha, Andishe Attarbaschi, Gabriele Escherich, Karsten Nysom, Jan Stary, Alina Ferster, Benoit Brethon, Franco Locatelli, Martin Schrappe, Peggy E. Scholte‐van Houtem, Maria G. Valsecchi, Rob Pieters, Inge M. van der Sluis   +14 more
wiley   +1 more source

Molecular Genetics of Stroke

Siriraj Medical Journal, 2008
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Manop Pithukpakorn
doaj  

PPM1G promotes cell proliferation via modulating mutant GOF p53 protein expression in hepatocellular carcinoma

iScience
Summary: The serine/threonine protein phosphatase family involves series of cellular processes, such as pre-mRNA splicing. The function of one of its members, protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), remains unclear in hepatocellular ...
Wen Hu, Shao-Lin Ma, Liang Qiong, Yu Du, Li-Ping Gong, Yu-Hang Pan, Li-Ping Sun, Jing-Yun Wen, Jian-Ning Chen, Xin-Yuan Guan, Chun-Kui Shao   +10 more
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Assessing structure-function impacts on Vitellogenin by leveraging allelic variant found in honey bee subspecies Apis mellifera mellifera

iScience
Summary: Advances involving artificial intelligence (AI) and experimental structure determination can provide detailed pictures of complex protein structures and their variations.
Vilde Leipart, Oriol Gracia Carmona, Christine Orengo, Franca Fraternali, Gro V. Amdam   +4 more
doaj   +1 more source

The molecular genetics of schizophrenia [PDF]

Neuropathology and Applied Neurobiology, 1994
There is strong evidence for a genetic component in schizophrenia but its precise nature remains unclear. Positional cloning and studies of potential candidate genes offer prospects for progress. The diagnosis of schizophrenia can now be made reliably but questions remain over the most valid phenotypic definition.
A G, Cardno, P, McGuffin
openaire   +2 more sources

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source