Results 131 to 140 of about 939,325 (312)

The fragile X locus is prone to spontaneous DNA damage that is preferentially repaired by nonhomologous end-joining to preserve genome integrity

iScience
Summary: A long CGG-repeat tract in the FMR1 gene induces the epigenetic silencing that causes fragile X syndrome (FXS). Epigenetic changes include H4K20 trimethylation, a heterochromatic modification frequently implicated in transcriptional silencing ...
Daman Kumari, Rachel Adihe Lokanga, Cai McCann, Thomas Ried, Karen Usdin   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Importance of secondary and tertiary genepools in barley genetics and breeding: I. Cytogenetics and molecular analysis

, 2004
There have been no plant breeding developments using species from the te1tiary genepool of cultivated barley for breeding or genetics since the VIIIth International Barley Genetics Symposium in 2000.
Ruge, Brigitte, Johnston, Paul A., Pickering, Richard   +2 more
core  

Meiosis, spermatogenesis and nucleolar behavior in the seminiferous tubules of Alydidae, Coreidae and Rhopalidae (Heteroptera) species.

, 2009
We studied the karyotype, spermatogenesis and nucleolar activity at spermatogenesis in five species of Heteropera: Hyalymenus sp and Neomegalotomus pallescens, Alydidae; Catorhintha guttula and Hypselonotus fulvus, Coreidae; and Niesthrea sidae ...
Souza, F.B., Itoyama, M.M., Souza, H.V., Castanhole, M.M.U., Maruyama, S.R.C.   +4 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Comparative study of the cytogenetic and molecular characteristics of Triatoma maculata and T. pseudomaculata (Heteroptera, Triatominae).

, 2010
Pos-graduacao em Genetica, Instituto de Biociencias, Letras e Ciencias Exatas, UNESP/IBILCE, Sao Jose do Rio Preto, SP, BrazilPos-graduacao em Genetica, Instituto de Biociencias, Letras e Ciencias Exatas, UNESP/IBILCE, Sao Jose do Rio Preto, SP ...
Mendonca, P.P., Mendonca, P.P. [UNESP]
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Molecular genetics and functional characterization of ciliopathies

Primary cilia are microtubule-based organelles projecting from most epithelial cells in vertebrates, with numerous essential roles in chemo- and mechanosensation. A suite of inherited human conditions are caused by defects in the structure or function of
Wheway, Gabrielle
core  

Lipid peroxidation and antioxidant capacity of G6PD-deficient patients with A-(202G>A) mutation

, 2009
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage.
Leite, Amauri Antiquera [UNESP], Souza, D. R S, Silveira, L. M. [UNESP], Silveira, L. M., Leite, Amauri Antiquera, Bonini-Domingos, C. R., Ondei, L. S. [UNESP], Pinhel, M. A S, Percário, S., Bonini-Domingos, C. R. [UNESP], Ricci, O., Ondei, L. S.   +11 more
core   +1 more source