Results 121 to 130 of about 939,325 (312)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Molecular genetics related to non-Hodgkin lymphoma

Open Life Sciences, 2016
Non-Hodgkin lymphoma (NHL) is a serious disease, with a high proportion of mortality. Molecular genetic abnormalities are very common in NHL, but specific characterization in accordance to molecular genetics for lymphoma subtypes is not yet completed ...
Guo Ming, Mao Xianglin, Ding Xiaoqing
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The molecular population genetics of HIV-1 group O

, 2004
HIV-1 group O originated through cross-species transmission of SIV from chimpanzees to humans and has established a relatively low prevalence in Central Africa.
Vandamme, Anne-Mieke, Lemey, Philippe, Vandamme, Anne Mieke, Drummond, Alexei J., Worobey, Michael, Rambaut, Andrew, Roques, Pierre, Pybus, Oliver G., Robertson, David L.   +8 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Molecular Genetics of Hypercholesterolemia

Annals of Medicine, 1990
(1990). Molecular Genetics of Hypercholesterolemia. Annals of Medicine: Vol. 22, No. 1, pp. 1-2.
openaire   +2 more sources

An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry

, 2017
Fast beta (20–28 Hz) electroencephalogram (EEG) oscillatory activity may be a useful endophenotype for studying the genetics of disorders characterized by neural hyperexcitability, including substance use disorders (SUDs).
Chorlian, D, Wetherill, L, Kamarajan, C, Goate, Alison, Almasy, L, Edenberg, Howard, Salvatore, JE, Kapoor, M, Wang, Jen-Chyong, Wetherill, Leah, Bucholz, KK, Pandey, Ashwini, Kuo, SI, Kramer, J, Agrawal, A, Foroud, T, Taylor, R E, Kuperman, S, Taylor, RE, Porjesz, B, Salvatore, J E, Scott, D, Koganti, L, Edenberg, HJ, Kuperman, Samuel, Foroud, Tatiana, Porjesz, Bernice, Bucholz, K K, Kramer, John, Su, J, Kuo, S I, Manz, N, Chorlian, David, Goate, A, Kamarajan, Chella, Bauer, L, Chan, G, Seay, M, Hesselbrock, V, Meyers, Jacquelyn, Wang, JC, Lai, D, Hesselbrock, Victor, Dick, DM, Bauer, Lance, Meyers, JL, Manz, Niklas, Dick, D M, Bertelsen, S, Zhang, J, Pandey, A   +50 more
core   +1 more source