Genetic code evolution as an initial driving force for molecular evolution [PDF]
Physica A 388 (2009) 3809-3825, 2008 There is an intrinsic relationship between the molecular evolution in primordial period and the properties of genomes and proteomes of contemporary species. The genomic data may help us understand the driving force of evolution of life at molecular level.
arxiv +1 more source
A molecular generative model with genetic algorithm and tree search for cancer samples [PDF]
arXiv, 2021 Personalized medicine is expected to maximize the intended drug effects and minimize side effects by treating patients based on their genetic profiles. Thus, it is important to generate drugs based on the genetic profiles of diseases, especially in anticancer drug discovery. However, this is challenging because the vast chemical space and variations in
arxiv
Molecular genetics of ependymoma [PDF]
Chinese Journal of Cancer, 2011 Brain tumors are the leading cause of cancer death in children, with ependymoma being the third most common and posing a significant clinical burden. Its mechanism of pathogenesis, reliable prognostic indicators, and effective treatments other than surgical resection have all remained elusive.
Yuan Yao +2 more
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Introduction to Molecular Genetics [PDF]
, 2020 In the last decades, molecular genetics has been rapidly integrated into the diagnostics of cardiovascular diseases, at first not only to solve well-defined familial cases but with the recent developments of next-generation sequencing (NGS) also to ...
Jongbloed, Jan D.H. +2 more
core +1 more source
External quality assessment of molecular biology-based methods used in laboratories of clinical chemistry and human genetics [PDF]
, 1998 The Reference Institute of Bioanalysis of the German Society of Clinical Chemistry has performed the first external assessment of molecular genetics methods used in medical diagnosis.
Braun, Andreas +6 more
core +1 more source
Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes
iScience, 2023 Summary: Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity caused by mutations in the autoimmune regulator (AIRE) gene.
Bergithe E. Oftedal +24 more
doaj
Synchronization of Coupled Nonidentical Genetic Oscillators [PDF]
Physical Biology 3 (2006) 37-44, 2006 The study on the collective dynamics of synchronization among genetic oscillators is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. Genetic oscillators are biochemical networks, which can generally be modelled as nonlinear dynamic systems.
arxiv +1 more source
Molecular Population Genetics [PDF]
Genetics, 2017 AbstractMolecular population genetics aims to explain genetic variation and molecular evolution from population genetics principles. The field was born 50 years ago with the first measures of genetic variation in allozyme loci, continued with the nucleotide sequencing era, and is currently in the era of population genomics.
Sònia Casillas, Antonio Barbadilla
openaire +2 more sources
Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]
, 2010 . We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Ferreira, C.F. +8 more
core +4 more sources
Using the molecular genetics methods for studying the peculiarities of muscle activity and inherited predisposition in the sport [PDF]
Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2013 Analyzes of the methods used in sports genetics, and molecular genetics of muscle activity in particular are considered. The historical retrospective review of sports genetics methods was created.
S.B. Drozdovska
doaj +2 more sources