Results 61 to 70 of about 7,162,052 (308)

Molecular identification of Ancylostoma ceylanicum in the Philippines

, 2020
Hookworms are some of the most widespread of the soil-transmitted helminths (STH) with an estimated 438.9 million people infected. Until relatively recently Ancylostoma ceylanicum was regarded as a rare cause of hookworm infection in humans, with little ...
Weerakoon, KG, Olveda, R, McManus, DP, Gordon, CA, Poise, AO, Ross, AG, Rogers, MJ   +6 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Metabolomic Profiles of a Midge (Procladius villosimanus, Kieffer) Are Associated with Sediment Contamination in Urban Wetlands

Metabolites, 2017
Metabolomic techniques are powerful tools for investigating organism-environment interactions. Metabolite profiles have the potential to identify exposure or toxicity before populations are disrupted and can provide useful information for environmental ...
Katherine J. Jeppe, Konstantinos A. Kouremenos, Kallie R. Townsend, Daniel F. MacMahon, David Sharley, Dedreia L. Tull, Ary A. Hoffmann, Vincent Pettigrove, Sara M. Long   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Comparison of Culture and Molecular Identification of Bacteria in Chronic Wounds

, 2012
Clinical diagnostics of chronic polymicrobial infections, such as those found in chronic wounds, represent a diagnostic challenge for both culture and molecular methods.
Randall D. Wolcott, Yan Sun, Daniel D. Rhoads, Scot E. Dowd   +3 more
core   +1 more source

Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats

Frontiers in Molecular Neuroscience
Prolonged or repeated exposure to stress elevates the risk of various psychological diseases, many of which are characterized by central nervous system dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs) are highly abundant in the
Chuan Wang, Qian Wang, Guangming Xu, Guangming Xu, Zhaoling Sun, Dong Zhang, Dong Zhang, Chunling Ma, Yingmin Li, Di Wen, Xiaojing Zhang, Bin Cong, Bin Cong   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessment of forensic individual identification and kinship analysis using transcript SNPs derived from public transcriptome sequencing data

BMC Genomics
Transcriptome sequencing data offer a valuable resource for inferring genetic variants, yet their application in forensic individual identification and kinship analysis remains insufficiently explored.
Weiping Zhang, Guanju Ma, Chaolong Lu, Lihong Fu, Bin Cong, Qian Wang, Shujin Li   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Molecular methods for the identification ofAspergillusspecies [PDF]

Medical Mycology, 2005
Invasive aspergillosis (IA) is a leading cause of morbidity and mortality in immunocompromised hosts. In some institutions, species of Aspergillus less susceptible to amphotericin B than Aspergillus fumigatus are becoming more common, making an accurate identification of species important.
Hinrikson, H.P., Hurst, S.F., de Aguirre, L., Hinrikson, H.P., Hurst, S.F., de Aguirre, L., Morrison, C.J.   +6 more
openaire   +3 more sources