Results 1 to 10 of about 12,274,852 (362)

Accurate image derived input function in [18F]SynVesT-1 mouse studies using isoflurane and ketamine/xylazine anesthesia

EJNMMI Physics, 2023
Background Kinetic modeling in positron emission tomography (PET) requires measurement of the tracer plasma activity in the absence of a suitable reference region.
Alan Miranda, Daniele Bertoglio, Steven Staelens, Jeroen Verhaeghe   +3 more
doaj   +1 more source

Performance evaluation of SIPM Photosensors for PET imaging in the presence of magnetic fields [PDF]

, 2009
[Poster] 4th European Molecular Imaging Meeting, Barcelona, Spain, May 27 - 30, 2009This work has been supported in part by MEC (FPA2007-62216), CDTEAM (Programa CENIT, Ministerio de Industria), UCM (Grupos UCM; 910059), CPAN (Consolider-Ingenio 2010 ...
Vicente, Esther, Fraile, L. M., Vaquero, Juan José, Herraiz, J. L., Desco Menéndez, Manuel, Desco, Manuel, España, Samuel, Udías, José Manuel, Vaquero López, Juan José   +8 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aminolysis-mediated single-step surface functionalization of poly (butyl cyanoacrylate) microbubbles for ultrasound molecular imaging

Journal of Nanobiotechnology
Molecular ultrasound imaging with actively targeted microbubbles (MB) proved promising in preclinical studies but its clinical translation is limited. To achieve this, it is essential that the actively targeted MB can be produced with high batch-to-batch
Junlin Chen, Bi Wang, Anshuman Dasgupta, Céline Porte, Lisa Eckardt, Jinwei Qi, Marek Weiler, Twan Lammers, Anne Rix, Yang Shi, Fabian Kiessling   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

EJNMMI Research, 2017
Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands—(R)-PK11195, PBR28, DPA-713, and ER176—to quantify ...
Masahiro Fujita, Masato Kobayashi, Masamichi Ikawa, Roger N. Gunn, Eugenii A. Rabiner, David R. Owen, Sami S. Zoghbi, Mohamad B. Haskali, Sanjay Telu, Victor W. Pike, Robert B. Innis   +10 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Quantitative Particle Identification (QPID) spectral autoradiography system

Communications Engineering
Autoradiography is used to study the distribution and binding of radioisotope tagged ligands in tissue at microscale among other applications. The technology has evolved since its inception when it used analogue film exposure techniques with the ...
Stephen S. Adler, Noriko Sato, Kwamena E. Baidoo, Frank I. Lin, Woonghee Lee, Colleen P. Olkowski, Freddy E. Escorcia, Peter L. Choyke   +7 more
doaj   +1 more source

Biomimetic and Functional Nanomaterials for Molecular Imaging

, 2023
Welcome to this Special Issue of the journal Pharmaceutics entitled “Biomimetic and Functional Nanomaterials for Molecular Imaging,” which focuses on the exciting advancements in molecular imaging facilitated by biomaterials and ...
Ramos Cabrer, Pedro, Pedro Ramos-Cabrer, Jesús Ruiz-Cabello, Ruiz-Cabello Osuna, Jesús   +3 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source