Results 181 to 190 of about 11,582,729 (334)

Ex14R58 vGluT2-3 from Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.

, 2014
Nicholas Collins Weiler, Forrest Collman, Joshua T Vogelstein, Randal Burns, Stephen J Smith   +4 more
openalex   +1 more source

Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans [PDF]

, 2011
Eugenii A. Rabiner, John D. Beaver, Aidan Makwana, Graham E. Searle, Christopher J. Long, Pradeep J. Nathan, Rexford D. Newbould, James Howard, Sam R. Miller, Mark Bush, Samuel P. Hill, Richard R. Reiley, Jan Passchier, Roger N. Gunn, Paul M. Matthews, Edward T. Bullmore   +15 more
openalex   +1 more source

Classification of Lung Cancer with Deep Learning Res-U-Net and Molecular Imaging [PDF]

, 2023
N. Malligeswari, G. Kavya
openalex   +1 more source

Inhibiting CXCR4 reduces immunosuppressive effects of myeloid cells in breast cancer immunotherapy

Scientific Reports
Patients with triple negative breast cancer (TNBC) show only modest response rates to immune checkpoint inhibitor immunotherapy, motivating ongoing efforts to identify approaches to boost efficacy.
Nicholas G. Ciavattone, Avinash Bevoor, Alex Farfel, Aasia Rehman, Kenneth K Y Ho, Edwin C. Rock, Yu-Chih Chen, Kathryn E. Luker, Brock A. Humphries, Gary D. Luker   +9 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Nanoscale Chromatin Imaging and Analysis (nano-ChIA) Platform Bridges 4-D Chromatin Organization with Molecular Function [PDF]

, 2020
Yue Li, Adam Eshein, Ranya Virk, Aya Eid, David VanDerway, Jane Frederick, Reiner Bleher, Igal Szleifer, Vinayak P. Dravid, Vadim Backman   +9 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

HER2 Targeted Molecular MR Imaging Using a De Novo Designed Protein Contrast Agent

, 2011
Jingjuan Qiao, Shunyi Li, Lixia Wei, Jie Jiang, Robert C. Long, Hui Mao, Ling Wei, Liya Wang, Hua Yang, Hans E. Grossniklaus, Zhi‐Ren Liu, Jenny J. Yang   +11 more
openalex   +2 more sources

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

<em>In Vivo</em> Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons [PDF]

, 2013
Vania Y. Cao, Yizhou Ye, Surjeet Mastwal, David M. Lovinger, Rui M. Costa, Kuan Hong Wang   +5 more
openalex   +1 more source