Results 181 to 190 of about 12,274,852 (362)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Translational PsychiatryThe N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is a robust, rapid-acting antidepressant whose molecular effects have not been fully elucidated. Phosphodiesterase-4 (PDE4), which terminates cyclic adenosine monophosphate (cAMP) activity, may
Paul A. Parcon +14 more
doaj +1 more source
FastPET reconstruction in whole-body 82-Rubidium molecular imaging [PDF]
openDeep learning-based PET image reconstruction has gained increasing attention due to its fast reconstruction times and low-count imaging capabilities. Fast reconstruction is particularly valuable for dynamic PET imaging, where multiple time frames are
BROVEDANI, ILARIA
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
In situ and in vitro cryo-EM reveal structures of mycobacterial encapsulin assembly intermediates
Communications BiologyProkaryotes rely on proteinaceous compartments such as encapsulin to isolate harmful reactions. Encapsulin are widely expressed by bacteria, including the Mycobacteriaceae, which include the human pathogens Mycobacterium tuberculosis and Mycobacterium ...
Casper Berger +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Cancer Immunology, ImmunotherapyTissue factor (TF) is a cell surface protein that plays a role in blood clotting but is also commonly expressed in many cancers. Recent research implicated TF in cancer proliferation, metastasis, angiogenesis, and immune escape.
Seiichiro Takao +10 more
doaj +1 more source
Towards Protein Network Analysis using TIS Imaging and Exploratory Data Analysis
, 2011 Langenkämper D, Kölling J, Khan M, Rajpoot N, Nattkemper TW. Towards Protein Network Analysis using TIS Imaging and Exploratory Data Analysis. Presented at the Workshop on Computational Systems Biology (WCSB), Zürich, Switzerland.Identification, analysis
Nattkemper, Tim Wilhelm ; https://orcid.org/ +4 more
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Advances in multimodal molecular imaging
, 2017 Preclinical molecular imaging is an emerging field. Improving the ability of scientists to study the molecular basis of human pathology in animals is of the utmost importance for future advances in all fields of human medicine.
Salvatore M. +11 more
core +1 more source