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An Overview of Target Membrane Proteins for Near-Infrared Photoimmunotherapy [PDF]

Pharmaceuticals
Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed cancer treatment that utilizes antibody–photoabsorber (IRDye700DX [IR700]) conjugates and NIR light.
Motofumi Suzuki, Hirofumi Hanaoka
doaj   +5 more sources

Near-Infrared Photoimmunotherapy in Brain Tumors—An Unexplored Frontier [PDF]

Pharmaceuticals
Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer treatment that uses near-infrared light to activate a conjugate of a monoclonal antibody (mAb) and a photoactivatable silica phthalocyanine dye (IRDye700DX: IR700).
Haruka Yamaguchi, Masayasu Okada, Takuya Otani, Jotaro On, Satoshi Shibuma, Toru Takino, Jun Watanabe, Yoshihiro Tsukamoto, Ryosuke Ogura, Makoto Oishi, Takamasa Suzuki, Akihiro Ishikawa, Hideyuki Sakata, Manabu Natsumeda   +13 more
doaj   +5 more sources

Near infrared photoimmunotherapy of cancer; possible clinical applications

Nanophotonics, 2021
Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an antibody-photo-absorber conjugate (APC) composed of a targeting monoclonal antibody conjugated with a photoactivatable phthalocyanine-derivative dye, IRDye700DX (IR700 ...
Wakiyama Hiroaki, Kato Takuya, Furusawa Aki, Choyke Peter L., Kobayashi Hisataka   +4 more
doaj   +4 more sources

Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective

Biomedicines, 2022
The conventional treatment of thoracic tumors includes surgery, anticancer drugs, radiation, and cancer immunotherapy. Light therapy for thoracic tumors has long been used as an alternative; conventional light therapy also called photodynamic therapy ...
Kohei Matsuoka, Mizuki Yamada, Mitsuo Sato, Kazuhide Sato   +3 more
doaj   +5 more sources

Interleukin 15 (IL15)-based near-infrared photoimmunotherapy [PDF]

Cancer Immunology, Immunotherapy
Near-infrared photoimmunotherapy (NIR-PIT) is a highly selective cancer therapy based on a targeted monoclonal antibody conjugated to phthalocyanine-based photoabsorber, IRDye700DX (IR700). Following injection, near-infrared light activates the conjugate
Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   +8 more
doaj   +4 more sources

Enhanced nanodrug delivery in tumors after near-infrared photoimmunotherapy [PDF]

Nanophotonics, 2019
To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts,
Inagaki Fuyuki F., Furusawa Aki, Choyke Peter L., Kobayashi Hisataka   +3 more
doaj   +3 more sources

Adding Intratumoral Antibody-Photoabsorber Conjugate Improves Efficacy of Near-Infrared Photoimmunotherapy (NIR-PIT). [PDF]

Cancer Sci
Intravenous (IV) or intratumoral (IT) cetuximab distribution in A431 tumor (essence of Figure 2). ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in ...
Kano M, Furusawa A, Takao S, Kano M, Suzuki M, Yamamoto H, Okuyama S, Kitamura K, Choyke PL, Kobayashi H.   +9 more
europepmc   +2 more sources

Near Infrared Photoimmunotherapy for Lung Cancer: Recent Development and Perspective [PDF]

ImmunoTargets and Therapy
Ryu Okada,1– 3,* Mizuki Yamada,1,3,4,* Mitsuo Sato,1,4 Kazuhide Sato1,3,51Graduate School of Medicine, Nagoya University, Nagoya, Japan; 2Research Unit for Life Sciences with Light Modulation, B3 Unit, Institute for Advanced Research ...
Okada R, Yamada M, Sato M, Sato K
doaj   +2 more sources

Synthetic zipper mediated pre-targeting system for near-infrared photoimmunotherapy [PDF]

iScience
Summary: Several strategies have gained attraction in cancer diagnosis and therapy, particularly to overcome the limitations associated with direct targeting approaches in radioimmunotherapy and photoimmunotherapy.
T.M. Mohiuddin, Chaoyu Zhang, Wenjie Sheng, Marwah Al-Rawe, Natalia El-Merhie, Felix Zeppernick, Ivo Meinhold-Heerlein, Ahmad Fawzi Hussain   +7 more
doaj   +2 more sources

Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin

Cells, 2020
Malignant pleural mesothelioma (MPM) has extremely limited treatment despite a poor prognosis. Moreover, molecular targeted therapy for MPM has not yet been implemented; thus, a new targeted therapy is highly desirable.
Yuko Nishinaga, Kazuhide Sato, Hirotoshi Yasui, Shunichi Taki, Kazuomi Takahashi, Misae Shimizu, Rena Endo, Chiaki Koike, Noriko Kuramoto, Shota Nakamura, Takayuki Fukui, Hiroshi Yukawa, Yoshinobu Baba, Mika K. Kaneko, Toyofumi F. Chen-Yoshikawa, Hisataka Kobayashi, Yukinari Kato, Yoshinori Hasegawa   +17 more
doaj   +3 more sources