Near infrared photoimmunotherapy of cancer; possible clinical applications
Nanophotonics, 2021 Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an antibody-photo-absorber conjugate (APC) composed of a targeting monoclonal antibody conjugated with a photoactivatable phthalocyanine-derivative dye, IRDye700DX (IR700 ...
Hiroaki Wakiyama +2 more
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Interleukin 15 (IL15)-based near-infrared photoimmunotherapy [PDF]
Cancer Immunology, ImmunotherapyNear-infrared photoimmunotherapy (NIR-PIT) is a highly selective cancer therapy based on a targeted monoclonal antibody conjugated to phthalocyanine-based photoabsorber, IRDye700DX (IR700). Following injection, near-infrared light activates the conjugate
Motofumi Suzuki +8 more
doaj +2 more sources
Near-Infrared Photoimmunotherapy in Brain Tumors—An Unexplored Frontier [PDF]
PharmaceuticalsNear-infrared photoimmunotherapy (NIR-PIT) is a promising cancer treatment that uses near-infrared light to activate a conjugate of a monoclonal antibody (mAb) and a photoactivatable silica phthalocyanine dye (IRDye700DX: IR700).
Haruka Yamaguchi +13 more
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Synthetic zipper mediated pre-targeting system for near-infrared photoimmunotherapy [PDF]
iScienceSummary: Several strategies have gained attraction in cancer diagnosis and therapy, particularly to overcome the limitations associated with direct targeting approaches in radioimmunotherapy and photoimmunotherapy.
T.M. Mohiuddin +7 more
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Near Infrared Photoimmunotherapy for Lung Cancer: Recent Development and Perspective [PDF]
ImmunoTargets and TherapyRyu Okada,1– 3,* Mizuki Yamada,1,3,4,* Mitsuo Sato,1,4 Kazuhide Sato1,3,51Graduate School of Medicine, Nagoya University, Nagoya, Japan; 2Research Unit for Life Sciences with Light Modulation, B3 Unit, Institute for Advanced Research ...
Okada R, Yamada M, Sato M, Sato K
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An Overview of Target Membrane Proteins for Near-Infrared Photoimmunotherapy [PDF]
PharmaceuticalsNear-infrared photoimmunotherapy (NIR-PIT) is a recently developed cancer treatment that utilizes antibody–photoabsorber (IRDye700DX [IR700]) conjugates and NIR light.
Motofumi Suzuki, Hirofumi Hanaoka
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Cells, 2020 Malignant pleural mesothelioma (MPM) has extremely limited treatment despite a poor prognosis. Moreover, molecular targeted therapy for MPM has not yet been implemented; thus, a new targeted therapy is highly desirable.
Yukinari Kato +2 more
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Enhanced nanodrug delivery in tumors after near‐infrared photoimmunotherapy
Nanophotonics, 2019 To date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts,
Aki Furusawa +2 more
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Recent advances in near-infrared dye conjugates for near-infrared photoimmunotherapy (NIR-PIT): enhancing therapeutic efficacy and immune mechanisms [PDF]
RSC Chemical BiologyNear-infrared photoimmunotherapy (NIR-PIT) is an innovative cancer treatment modality that was approved in Japan in 2020 for the treatment of unresectable locally advanced or locally recurrent head and neck cancer.
Yoshikazu Fuse +4 more
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Near-infrared photoimmunotherapy in cancer treatment: a bibliometric and visual analysis [PDF]
Frontiers in PharmacologyBackgroundNear-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer treatment technology that combines the advantages of optical technology and immunotherapy to provide a highly effective, precise, and low side-effect treatment approach.
Jinglin Tian +3 more
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