CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma model [PDF]
OncoImmunology, 2022 Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that utilizes an antibody-photoabsorber-conjugate (AbPC) combined with NIR light.
Hiroaki Wakiyama +2 more
exaly +6 more sources
Disialoganglioside GD2-Targeted Near-Infrared Photoimmunotherapy (NIR-PIT) in Tumors of Neuroectodermal Origin [PDF]
Pharmaceutics, 2022 Disialoganglioside (GD2) is a subtype of glycolipids that is highly expressed in tumors of neuroectodermal origins, such as neuroblastoma and osteosarcoma.
Hiroaki Wakiyama +2 more
exaly +6 more sources
EpCAM-targeted near-infrared photoimmunotherapy (NIR-PIT) for the treatment of breast cancer [PDF]
Annals of MedicineBackground Near-infrared photoimmunotherapy (NIR-PIT) is a targeted cancer treatment that uses antibody-IR700 conjugates and selectively destroys cancer cells expressing a target antigen when exposed to near-infrared (NIR) light.
Aki Furusawa +2 more
exaly +6 more sources
Antibody Drug Conjugates of Near-Infrared Photoimmunotherapy (NIR-PIT) in Breast Cancers [PDF]
Technology in Cancer Research and Treatment, 2023 Worldwide, the incidence rate of breast cancer is the highest in women. Approximately 2.3 million people were newly diagnosed and 0.685 million were dead of breast cancer in 2020, which continues to grow.
Xiaosong Li, Yuanyuan Xu, Cui Yingshu
exaly +5 more sources
Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer [PDF]
Scientific Reports, 2021 Cancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs have the multifunctionality which strongly support cancer progression and the acquisition of therapeutic resistance by cancer cells.
Shunsuke Kagawa +2 more
exaly +8 more sources
Near-infrared photoimmunotherapy (NIR-PIT) of bone metastases [PDF]
Biomedicine and Pharmacotherapy, 2023 The bones are a common site for metastasis arising from solid tumors such as breast and prostate cancer. Chemotherapy, including immunotherapy, is rarely curative. Radiotherapy with pain palliation can temporize bone metastases but is generally considered a short-term solution and retreatment is difficult. Surgery is often necessary, yet recovery times
Seiichiro Takao +2 more
exaly +4 more sources
Near-Infrared Photoimmunotherapy (NIR-PIT) in Urologic Cancers [PDF]
Cancers, 2022 Near-infrared photoimmunotherapy (NIR-PIT) is a novel molecularly-targeted therapy that selectively kills cancer cells by systemically injecting an antibody-photoabsorber conjugate (APC) that binds to cancer cells, followed by the application of NIR light that drives photochemical transformations of the APC.
Peter A Pinto +2 more
exaly +4 more sources
Endoscopic Applications of Near-Infrared Photoimmunotherapy (NIR-PIT) in Cancers of the Digestive and Respiratory Tracts [PDF]
Biomedicines, 2022 Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed and promising therapy that specifically destroys target cells by irradiating antibody-photo-absorber conjugates (APCs) with NIR light. APCs bind to target molecules on the cell surface, and when exposed to NIR light, cause disruption of the cell membrane due to the ligand release reaction ...
Hiroaki Wakiyama +2 more
exaly +5 more sources
Near‐infrared photoimmunotherapy (NIR‐PIT) on cholangiocarcinoma using a novel catheter device with light emitting diodes [PDF]
Cancer Science, 2021 AbstractNear‐infrared photoimmunotherapy (NIR‐PIT) is a novel therapy for cancers that uses NIR light and antibody‐photosensitizer (IR700) conjugates. However, it is difficult to deliver NIR light into the bile duct for cholangiocarcinoma (CCA) from the conventional extracorporeal apparatus.
Masaki Kuwatani +2 more
exaly +6 more sources
Recent Advances in Localized Immunomodulation Technology: Application of NIR-PIT toward Clinical Control of the Local Immune System [PDF]
Pharmaceutics, 2023 Current immunotherapies aim to modulate the balance among different immune cell populations, thereby controlling immune reactions. However, they often cause immune overactivation or over-suppression, which makes them difficult to control.
Mizuki Yamada +3 more
doaj +4 more sources