Results 1 to 10 of about 2,721 (168)

Overcoming resistant cancerous tumors through combined photodynamic and immunotherapy (photoimmunotherapy) [PDF]

Frontiers in Immunology
Cancer is a major health problem as it causes significant mortality globally. In the last decades, conventional and recent therapeutic approaches have been used in oncology for cancer treatment.
Glory Kah, Heidi Abrahamse
doaj   +3 more sources

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer [PDF]

Advanced Science
Pancreatic cancer (PC) features dense stromal barriers and profound immune exclusion, rendering it largely unresponsive to immunotherapy. Here, we present ICyM2, a carrier‐free and esterase‐responsive nanoaggregate rationally designed by covalently ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
doaj   +3 more sources

EGFR-targeted photoimmunotherapy and its association with the immune microenvironment in locoregional recurrent head and neck squamous cell carcinoma [PDF]

Frontiers in Immunology
BackgroundEpidermal growth factor receptor (EGFR)-targeted photoimmunotherapy using cetuximab sarotalocan sodium (RM-1929) represents a novel therapeutic modality that induces selective tumor cell death and may influence the tumor immune microenvironment
Koichi Yoshizawa, Takahiro Tsujikawa, Takahiro Tsujikawa, Peesit Leelasawatsuk, Peesit Leelasawatsuk, Mai Mohamed Bedeir, Yuna van der Aar, Tim de Martines, Saya Shibata, Hiroshi Ogi, Hiroshi Ogi, Ryuhei Okada, Alisa Kimura, Hiroki Morimoto, Sumiyo Saburi, Shigeyuki Mukudai, Hikaru Nagao, Aya Miyagawa-Hayashino, Eiichi Konishi, Kyoko Itoh, Takahiro Asakage, Shigeru Hirano   +21 more
doaj   +2 more sources

Safety and Efficacy Findings From a Phase Ib/II Study of ASP-1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma. [PDF]

Head Neck
ASP‐1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing.
Cognetti DM, Curry JM, Johnson J, Kwon M, Su SY, Civantos F, Olazagasti C, Valentino J, Arnold SM, Bell RB, Gibson MK, Mannion K, Van Abel KM, Price KA, Dong H, Thorne AH, Suzuki T, Gillenwater AM.   +17 more
europepmc   +2 more sources

Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy‐Atom‐Free Photosensitizers‐Based Combination Therapies to Boost Cancer Photoimmunotherapy

Advanced Science
Near‐infrared (NIR) activated photosensitizers based on heavy‐atom‐free have great advantages in photoimmunotherapy, yet the tumor microenvironment often restricts their efficacy. To address this, a NIR‐activated heavy‐atom‐free photosensitizer (named Cy‐
Yongjian Zhang, Xiaohong Wu, Kaiyuan Wang, Yaohan Tang, Xiuxin Lu, Fusheng Sun, Hua Tang, Xiaoyuan Chen, Shipeng Ning   +8 more
doaj   +2 more sources

A photoimmune synergizing RNA interference technology for highly effective antitumor treatment. [PDF]

Smart Mol
We developed a red‐light‐activated small‐molecule photosensitizer FNBS, which enables simultaneous photodynamic immunotherapy and RNA interference. FNBS can induce pyroptosis, immunogenic cell death and RNA degradation, avoiding the carrier‐dependent delivery drawbacks of conventional RNAi therapy, converting cold tumors into hot tumors and ...
Xia X, Wu B, Zhao X, Sun W, Du J, Fan J, Peng X.   +6 more
europepmc   +2 more sources

Photoactivated iridium(III) complexes drive pyroptosis-necroptosis synergy for multi-network photoimmunotherapy of renal cell carcinoma. [PDF]

Smart Mol
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Qin X, Chen MD, Gao W, Wang Y, Liu LQ, Teng Z, Qi T, Wang Q, Wang Y, Li D, Yan K, Pan L, Zhao Z, Zhao S, Wang KN, Fu S, Yu N.   +16 more
europepmc   +2 more sources

Targeted Photo-Induced Elimination of Tumor-Associated Macrophages Suppresses Cancer Progression in a Murine Model. [PDF]

Cancer Sci
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Nakajima K, Uchiyama T, Funayama K, Goto Y, Mukaimine A, Ieda N, Ogawa M.   +6 more
europepmc   +2 more sources

Adding Intratumoral Antibody-Photoabsorber Conjugate Improves Efficacy of Near-Infrared Photoimmunotherapy (NIR-PIT). [PDF]

Cancer Sci
Intravenous (IV) or intratumoral (IT) cetuximab distribution in A431 tumor (essence of Figure 2). ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in ...
Kano M, Furusawa A, Takao S, Kano M, Suzuki M, Yamamoto H, Okuyama S, Kitamura K, Choyke PL, Kobayashi H.   +9 more
europepmc   +2 more sources

Immunological Significance of the ICI–PIT–ICI Sequence in Recurrent Oral Cancer: A Narrative Review with Illustrative Cases [PDF]

Diagnostics
Immune checkpoint inhibitors (ICIs) have improved clinical outcomes in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC).
Taiki Suzuki, Kenichi Kumagai, On Hasegawa, Taro Okui, Reo Aoki, Koichiro Kato, Chieko Masuda, Yoshihiro Ohashi, Yoshiki Hamada, Akihisa Horie   +9 more
doaj   +2 more sources