Results 41 to 50 of about 3,309 (240)

Endoscopic Molecular Imaging plus Photoimmunotherapy: A New Strategy for Monitoring and Treatment of Bladder Cancer

Molecular Therapy: Oncolytics, 2020
Due to the high recurrence and progression rate of non-muscle invasive bladder cancer after transurethral resection of bladder tumor, some new optical imaging technologies have arisen as auxiliary imaging modes for white light cystoscopy to improve the ...
Yongjun Yang, Chao Liu, Xiaofeng Yang
doaj   +1 more source

Current Challenges and Opportunities of Photodynamic Therapy against Cancer

Pharmaceutics, 2023
BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are generated that ultimately induce cell death and disruption of the tumor area. Moreover, PDT
Ruben V. Huis in ‘t Veld, Jeroen Heuts, Sen Ma, Luis J. Cruz, Ferry A. Ossendorp, Martine J. Jager   +5 more
doaj   +1 more source

Near‐infrared photoimmunotherapy through bone [PDF]

Cancer Science, 2019
AbstractNear‐infrared photoimmunotherapy (NIR‐PIT) is a molecularly targeted cancer phototherapy that is based on injecting a conjugate of a silicon‐phthalocyanine derivative, IRdye 700DX (IR700), and a monoclonal antibody that targets an expressed antigen on the cancer cell surface.
Yu A. Nakamura, Shuhei Okuyama, Aki Furusawa, Tadanobu Nagaya, Daiki Fujimura, Ryuhei Okada, Yasuhiro Maruoka, Philip C. Eclarinal, Peter L. Choyke, Hisataka Kobayashi   +9 more
openaire   +2 more sources

A Sensitive Gas Chromatography-Mass Spectrometry Assay Reveals Increased Levels of Monohydroxyeicosatetraenoic Acid Isomers in Human Plasma After Extracorporeal Photoimmunotherapy and Under In Vitro Ultraviolet A Exposure [PDF]

, 2000
SummaryExtracorporeal photoimmunotherapy (photopheresis) is a highly effective therapy in the treatment of various disorders. Although extracorporeal photoimmunotherapy has been successfully used for more than 10 y, its mechanism of action is still ...
Wiswedel, Ingrid, Kühn, Hartmut, Augustin, Wolfgang, Hirsch, Daniela, Bohne, Marisela, Gollnick, Harald   +5 more
core   +1 more source

Receptor-Mediated DNA-Targeted Photoimmunotherapy [PDF]

Cancer Research, 2006
Abstract We show the efficacy of a therapeutic strategy that combines the potency of a DNA-binding photosensitizer, UVASens, with the tumor-targeting potential of receptor-mediated endocytosis. The photosensitizer is an iodinated bibenzimidazole, which, when bound in the minor groove of DNA and excited by UVA irradiation, induces ...
Tom C, Karagiannis, Pavel N, Lobachevsky, Brenda K Y, Leung, Jonathan M, White, Roger F, Martin   +4 more
openaire   +2 more sources

Near infrared photoimmunotherapy for lung metastases [PDF]

Cancer Letters, 2015
Lung metastases are a leading cause of cancer related deaths; nonetheless current treatments are limited. Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies that target tumors with the toxicity induced by photosensitizers activated by NIR-light.
Kazuhide, Sato, Tadanobu, Nagaya, Makoto, Mitsunaga, Peter L, Choyke, Hisataka, Kobayashi   +4 more
openaire   +2 more sources

Insight into the Prospects for Tumor Therapy Based on Photodynamic Immunotherapy

Pharmaceuticals, 2022
Malignancy is one of the common diseases with high mortality worldwide and the most important obstacle to improving the overall life expectancy of the population in the 21st century.
Xiaoxia Cheng, Yiqu Wei, Xiaomei Jiang, Chunli Wang, Mengyu Liu, Jiaxin Yan, Lei Zhang, Yaqi Zhou   +7 more
doaj   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, EarlyView.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +2 more sources

Mace‐Like Plasmonic Au‐Pd Heterostructures Boost Near‐Infrared Photoimmunotherapy

Advanced Science, 2023
Photoimmunotherapy, with spatiotemporal precision and noninvasive property, has provided a novel targeted therapeutic strategy for highly malignant triple‐negative breast cancer (TNBC).
Yanlin Feng, Xin Ning, Jianlin Wang, Zhaoyang Wen, Fangfang Cao, Qing You, Jianhua Zou, Xin Zhou, Teng Sun, Jimin Cao, Xiaoyuan Chen   +10 more
doaj   +1 more source