Results 1 to 10 of about 503,784 (164)

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

Neural Regeneration Research, 2022
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s disease.
Heba M Mansour, Hala M Fawzy, Aiman S El-Khatib, Mahmoud M Khattab   +3 more
doaj   +1 more source

An EGFR T790M-mutated lung adenocarcinoma undergoing large-cell neuroendocrine carcinoma transformation after osimertinib therapy: a case report

Journal of Medical Case Reports, 2020
Background Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is selective for both epidermal growth factor receptor tyrosine kinase inhibitor–sensitizing and T790M resistance mutations.
Shinichi Miyazaki, Yasumasa Kuno, Shunsaku Hayai, Ryo Teramachi, Ryo Yamashita, Yusuke Saito, Kosuke Higuchi, Yoshiharu Nara, Takuya Ikeda   +8 more
doaj   +1 more source

Outcome of Epidermal Growth Factor Receptor Mutated and Non Mutated Adenocarcinoma Lung to Standard Therapy

Journal of Nepal Health Research Council, 2023
Background: Asian patients with adenocarcinoma of lung have higher incidence of epidermal growth factor receptor mutations which predict increased response and survival in patients to oral tyrosine kinase inhibitors.
Soniya Dulal, Akshat Mishra, Aarati Shah, Bibek Acharya, Ramila Shilpakar, Sandhya Chapagain Acharya, Ambuj Karn, Rajeev Sharma, Balram Gautam, Bishnu Dutta Paudel   +9 more
doaj   +1 more source

Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases. [PDF]

PLoS ONE, 2015
Antiangiogenic agents have been widely investigated in combination with standard chemotherapy or targeted cancer agents for better management of advanced cancers.
Jiho Song, Jakyung Yoo, Ara Kwon, Doran Kim, Hong Khanh Nguyen, Bong-Yong Lee, Wonhee Suh, Kyung Hoon Min   +7 more
doaj   +1 more source

Epidermal growth factor receptor (EGFR) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort [PDF]

, 2019
Background: Epidermal growth factor receptor (EGFR) is a member of the ErbB family of tyrosine kinase receptor proteins that plays important roles in tumour cell survival and proliferation.
Abdul Raub, Sayyidi Hamzi, Azhari, Azlah Kamilah, Eswaran, Jeyanthy, Soundararajan, Meera, Syed Husain, Sharifah Noor Akmal, Wan Hasan, Wan Atiqah Najiah, Zakaria, Zubaidah, Zulkifle, Muhamad Farid   +7 more
core   +1 more source

Inhibiting epidermal growth factor receptor at a distance. [PDF]

, 2014
The epidermal growth factor receptor (EGFR) tyrosine kinase is implicated in a large number of human cancers. Most EGFR inhibitors target the extracellular, growth factor-binding domain or the intracellular, ATP-binding domain. Here we describe molecules
Denton, Elizabeth, Schepartz, Alanna, Sinclair, Julie   +2 more
core   +2 more sources

Epidermal Growth Factor Receptor immunohistochemical expression in hepatocellular carcinoma without Epidermal Growth Factor Receptor exons 18–21 mutations

Romanian Journal of Internal Medicine, 2022
Introduction: EGFR targeted therapies, have been proved beneficial for patients with HCC, nevertheless additional research on EGFR immunoexpresion and EGFR mutations is still needed, especially in population in which it has not been done yet.
Nikolova Dafina, Trajkovska Meri, Trpcevska Emilija Nikolovska, Eftimov Aleksandar, Jovanovik Rubens, Janevska Vesna   +5 more
doaj   +1 more source

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

Intraocular Metastases Secondary to Breast Carcinoma Correlates With Upregulation of Estrogen and Progesterone Receptor Expression in the Primary Tumor [PDF]

, 2016
To compare estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptor expression in the primary tumor of patients affected by choroidal metastases from breast carcinoma (BC) versus those with extraocular ...
Frizziero, Luisa, Midena, Edoardo, Miglionico, Giacomo, Parrozzani, Raffaele, Perrini, Pierdavide, Pilotto, Elisabetta, Pulze, Serena, Testi, Ilaria   +7 more
core   +1 more source

Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4)

Tumor Biology, 2017
The use of trastuzumab in patients with breast cancer that overexpresses human epidermal growth factor receptor 2 has significantly improved treatment outcomes.
Marianne Nordlund Broughton, Arne Westgaard, Elisabeth Paus, Miriam Øijordsbakken, Karoline J Henanger, Bjørn Naume, Trine Bjøro   +6 more
doaj   +1 more source