Results 21 to 30 of about 9,744,428 (293)
Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases. [PDF]
PLoS ONE, 2015 Antiangiogenic agents have been widely investigated in combination with standard chemotherapy or targeted cancer agents for better management of advanced cancers.
Jiho Song +7 more
doaj +1 more source
Pakistan Armed Forces Medical Journal, 2023 Objective: To determine the association between human epidermal growth factor receptor 2 with age among patients presenting with breast cancer. Study Design: Comparative cross-sectional study.
Mahnoor Ahsan +5 more
doaj +1 more source
The epidermal growth factor receptor conundrum [PDF]
Cancer, 2010 Soluble epidermal growth factor receptor (sEGFR), a cell surface and serum protein derived from an alternately spliced human EGFR transcript, is recognized by 2 therapeutic antibodies approved by the US Food and Drug Administration: cetuximab and panitumumab.
Jason A, Wilken +2 more
openaire +2 more sources
The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-alpha [PDF]
, 2002 Heparin-binding epidermal growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is implicated in a variety of biological processes, including reproduction.
Mardon, Helen J. +23 more
core +1 more source
Epidermal growth factor receptor signaling [PDF]
Current Biology, 2001 Inhibitory signaling is an important way of fine tuning EGFR activity to enable a cell to discriminate between short and prolonged exposure to signaling molecules. Over the last few years a number of different mechanisms have been shown to abrogate receptor activity (Fig. 3Fig. 3). First, inhibitory signaling molecules are expressed in response to EGFR
Bogdan, Sven, Klämbt, Christian
openaire +2 more sources
Romanian Journal of Internal Medicine, 2022 Introduction: EGFR targeted therapies, have been proved beneficial for patients with HCC, nevertheless additional research on EGFR immunoexpresion and EGFR mutations is still needed, especially in population in which it has not been done yet.
Nikolova Dafina +5 more
doaj +1 more source
The role of recombinant epidermal growth factor and serotonin in the stimulation of tumor growth in a SCCHN xenograft model [PDF]
, 2012 One challenge of squamous cell carcinoma of the head and neck (SCCHN) chemotherapy is a small percentage of tumor cells that arrest in the G0 phase of the cell cycle and are thus not affected by chemotherapy. This could be one reason for tumor recurrence
Arnoldner, Christoph +6 more
core +1 more source
Tumor Biology, 2017 The use of trastuzumab in patients with breast cancer that overexpresses human epidermal growth factor receptor 2 has significantly improved treatment outcomes.
Marianne Nordlund Broughton +6 more
doaj +1 more source
Update on HER-2 as a target for cancer therapy: alternative strategies for targeting the epidermal growth factor system in cancer [PDF]
, 2001 The epidermal growth factor (EGF) family of ligands and receptors interact to influence cell division, differentiation and motility. Much evidence supports their importance in causing and sustaining cell transformation in model systems and in human ...
Gullick, William J.
core +1 more source
Genome Medicine, 2017 Targeted therapies such as kinase inhibitors and monoclonal antibodies have dramatically altered cancer care in recent decades. Although these targeted therapies have improved patient outcomes in several cancer types, resistance ultimately develops to ...
Leanne G. Ahronian, Ryan B. Corcoran
doaj +1 more source